PDF(Pubmed)
Abstract：
BACKGROUND: The Lipid Accumulation Product (LAP) is a measure that indicates excessive fat accumulation in the body. LAP has been the focus of research in epidemiological studies aimed at forecasting chronic and metabolic diseases. This study aimed to evaluate the association between LAP and type 2 diabetes mellitus (T2DM) among adults in western Iran.
METHODS: The study involved 9,065 adults who participated in the initial phase of the Ravansar non-communicable diseases study (RaNCD) cohort. To investigate the association between LAP and T2DM, multiple logistic regressions were employed. Additionally, the receiver operating characteristic (ROC) curve was used to evaluate LAP\'s predictive ability concerning T2DM.
RESULTS: The participants had an average age of 47.24 ± 8.27 years, comprising 49.30% men and 50.70% women. The mean LAP was 53.10 ± 36.60 for the healthy group and 75.51 ± 51.34 for the diabetic group (P < 0.001). The multiple regression analysis revealed that the odds of T2DM in the second quartile of LAP were 1.69 (95% CI: 1.25, 2.29) times greater than in the first quartile. Furthermore, the odds in the third and fourth quartiles were 2.67 (95% CI: 2.01, 3.55) and 3.73 (95% CI: 2.83, 4.92) times higher, respectively. The ROC analysis for predicting T2DM showed that the LAP index had an area under the curve (AUC) of 0.66 (95% CI: 0.64, 0.68).
CONCLUSIONS: A strong association was identified between elevated LAP levels and T2DM in the adult population of western Iran. LAP is recommended as a potential tool for screening diabetes susceptibility.
METHODS: The study involved 9,065 adults who participated in the initial phase of the Ravansar non-communicable diseases study (RaNCD) cohort. To investigate the association between LAP and T2DM, multiple logistic regressions were employed. Additionally, the receiver operating characteristic (ROC) curve was used to evaluate LAP\'s predictive ability concerning T2DM.
RESULTS: The participants had an average age of 47.24 ± 8.27 years, comprising 49.30% men and 50.70% women. The mean LAP was 53.10 ± 36.60 for the healthy group and 75.51 ± 51.34 for the diabetic group (P < 0.001). The multiple regression analysis revealed that the odds of T2DM in the second quartile of LAP were 1.69 (95% CI: 1.25, 2.29) times greater than in the first quartile. Furthermore, the odds in the third and fourth quartiles were 2.67 (95% CI: 2.01, 3.55) and 3.73 (95% CI: 2.83, 4.92) times higher, respectively. The ROC analysis for predicting T2DM showed that the LAP index had an area under the curve (AUC) of 0.66 (95% CI: 0.64, 0.68).
CONCLUSIONS: A strong association was identified between elevated LAP levels and T2DM in the adult population of western Iran. LAP is recommended as a potential tool for screening diabetes susceptibility.
摘要：
背景：脂质积累产物（LAP）是一种指示体内过多脂肪积累的量度。LAP一直是旨在预测慢性和代谢性疾病的流行病学研究的重点。本研究旨在评估伊朗西部成年人LAP与2型糖尿病（T2DM）之间的关系。
方法：该研究涉及9,065名成年人，他们参加了Ravansar非传染性疾病研究（RaNCD）队列的初始阶段。为了研究LAP和T2DM之间的关联，采用多元逻辑回归。此外,受试者工作特征（ROC）曲线用于评估LAP对T2DM的预测能力。
结果：参与者的平均年龄为47.24±8.27岁，男性占49.30%，女性占50.70%。健康组平均LAP为53.10±36.60,糖尿病组平均LAP为75.51±51.34(P<0.001)。多元回归分析显示，LAP第二个四分位数的T2DM几率是第一个四分位数的1.69倍（95％CI：1.25，2.29）。此外，第三和第四四分位数的赔率分别为2.67倍(95%CI:2.01,3.55)和3.73倍(95%CI:2.83,4.92),分别。预测T2DM的ROC分析显示LAP指数的曲线下面积(AUC)为0.66(95%CI:0.64,0.68)。
结论：在伊朗西部的成年人口中，LAP水平升高与T2DM之间有很强的关联。LAP被推荐作为筛查糖尿病易感性的潜在工具。
方法：该研究涉及9,065名成年人，他们参加了Ravansar非传染性疾病研究（RaNCD）队列的初始阶段。为了研究LAP和T2DM之间的关联，采用多元逻辑回归。此外,受试者工作特征（ROC）曲线用于评估LAP对T2DM的预测能力。
结果：参与者的平均年龄为47.24±8.27岁，男性占49.30%，女性占50.70%。健康组平均LAP为53.10±36.60,糖尿病组平均LAP为75.51±51.34(P<0.001)。多元回归分析显示，LAP第二个四分位数的T2DM几率是第一个四分位数的1.69倍（95％CI：1.25，2.29）。此外，第三和第四四分位数的赔率分别为2.67倍(95%CI:2.01,3.55)和3.73倍(95%CI:2.83,4.92),分别。预测T2DM的ROC分析显示LAP指数的曲线下面积(AUC)为0.66(95%CI:0.64,0.68)。
结论：在伊朗西部的成年人口中，LAP水平升高与T2DM之间有很强的关联。LAP被推荐作为筛查糖尿病易感性的潜在工具。
