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Abstract：
OBJECTIVE: Zygomycosis, a severe form of fungal infection, is classified into two categories: Mucorales and Entomophthorales. Within the Entomophthorales category, Basidiobolomycosis is a rarely recognized genus that can have significant health implications. Prompt diagnosis and appropriate treatment, which includes the use of antifungal medication and surgical procedures, are vital for enhancing the prognosis of patients. The objective of this study is to investigate the response to treatment in patients hospitalized due to basidiobolomycosis.
METHODS: We carried out a retrospective study, in which we analyzed data from 49 patients who were diagnosed with Entomophthorale, Zygomycosis, and Basidiobolomycosis at Namazi Hospital, Shiraz, between the years 1997 and 2019. The data included parameters such as demographic information, clinical symptoms, imaging findings, treatment methods, and patient outcomes.
RESULTS: Out of 49 patients, 24 children, predominantly male (83.3%), were definitively diagnosed with basidiobolomycosis. The ages of the patients ranged from 1 to 16 years, with an average of 5.75 years. The most frequently observed clinical manifestations included abdominal pain (70.8%), fever (54.2%), hematochezia (41.7%), vomiting (20.8%), and anorexia (16.7%). Half of the patients exhibited failure to thrive (FTT), while abdominal distension was present in 25% of the cases, and a palpable abdominal mass was found in 37% of the patients. The primary treatment strategy incorporated surgical interventions complemented by a comprehensive antifungal regimen. This regimen included medications such as amphotericin B, cotrimoxazole, itraconazole, potassium iodide, and voriconazole. These were mainly administered in a combination therapy pattern or as a monotherapy of amphotericin B. Twenty-two patients were discharged, while two patients died due to complications from the disease.
CONCLUSIONS: Our findings indicate that the prevailing treatment modalities generally involve surgical intervention supplemented by antifungal regimens, including Amphotericin B, Cotrimoxazole, Potassium Iodide, and Itraconazole.
METHODS: We carried out a retrospective study, in which we analyzed data from 49 patients who were diagnosed with Entomophthorale, Zygomycosis, and Basidiobolomycosis at Namazi Hospital, Shiraz, between the years 1997 and 2019. The data included parameters such as demographic information, clinical symptoms, imaging findings, treatment methods, and patient outcomes.
RESULTS: Out of 49 patients, 24 children, predominantly male (83.3%), were definitively diagnosed with basidiobolomycosis. The ages of the patients ranged from 1 to 16 years, with an average of 5.75 years. The most frequently observed clinical manifestations included abdominal pain (70.8%), fever (54.2%), hematochezia (41.7%), vomiting (20.8%), and anorexia (16.7%). Half of the patients exhibited failure to thrive (FTT), while abdominal distension was present in 25% of the cases, and a palpable abdominal mass was found in 37% of the patients. The primary treatment strategy incorporated surgical interventions complemented by a comprehensive antifungal regimen. This regimen included medications such as amphotericin B, cotrimoxazole, itraconazole, potassium iodide, and voriconazole. These were mainly administered in a combination therapy pattern or as a monotherapy of amphotericin B. Twenty-two patients were discharged, while two patients died due to complications from the disease.
CONCLUSIONS: Our findings indicate that the prevailing treatment modalities generally involve surgical intervention supplemented by antifungal regimens, including Amphotericin B, Cotrimoxazole, Potassium Iodide, and Itraconazole.
摘要：
目的：真菌病，一种严重的真菌感染,分为两类：毛囊菌和口囊菌。在昆虫类类别中，Basidiobolomcosis是一种很少被认可的属，可能对健康产生重大影响。及时诊断和适当治疗，其中包括使用抗真菌药物和外科手术，对提高患者预后至关重要。这项研究的目的是调查由于担子菌病住院的患者对治疗的反应。
方法：我们进行了一项回顾性研究，其中我们分析了49例诊断为口蹄疫的患者的数据，真菌病,和纳马齐医院的基底菌病，设拉子,在1997年至2019年之间。数据包括人口统计信息等参数，临床症状,影像学发现，治疗方法,和患者结果。
结果：在49例患者中，24个孩子,以男性为主（83.3%），明确诊断为担子菌病。患者的年龄从1岁到16岁不等，平均为5.75年。最常见的临床表现包括腹痛（70.8%）。发烧（54.2%），便血(41.7%)，呕吐(20.8%),和厌食症(16.7%)。一半的患者表现出未能茁壮成长（FTT），而25%的病例存在腹胀，在37%的患者中发现了明显的腹部肿块。主要治疗策略包括手术干预，并辅以全面的抗真菌治疗方案。该方案包括药物如两性霉素B，复方新诺明,伊曲康唑,碘化钾,和伏立康唑.这些药物主要以联合治疗模式或两性霉素B的单一疗法给药。而两名患者因并发症死亡。
结论：我们的研究结果表明，目前的治疗方式通常包括手术干预，辅以抗真菌治疗方案，包括两性霉素B,复方新诺明,碘化钾,和伊曲康唑.
方法：我们进行了一项回顾性研究，其中我们分析了49例诊断为口蹄疫的患者的数据，真菌病,和纳马齐医院的基底菌病，设拉子,在1997年至2019年之间。数据包括人口统计信息等参数，临床症状,影像学发现，治疗方法,和患者结果。
结果：在49例患者中，24个孩子,以男性为主（83.3%），明确诊断为担子菌病。患者的年龄从1岁到16岁不等，平均为5.75年。最常见的临床表现包括腹痛（70.8%）。发烧（54.2%），便血(41.7%)，呕吐(20.8%),和厌食症(16.7%)。一半的患者表现出未能茁壮成长（FTT），而25%的病例存在腹胀，在37%的患者中发现了明显的腹部肿块。主要治疗策略包括手术干预，并辅以全面的抗真菌治疗方案。该方案包括药物如两性霉素B，复方新诺明,伊曲康唑,碘化钾,和伏立康唑.这些药物主要以联合治疗模式或两性霉素B的单一疗法给药。而两名患者因并发症死亡。
结论：我们的研究结果表明，目前的治疗方式通常包括手术干预，辅以抗真菌治疗方案，包括两性霉素B,复方新诺明,碘化钾,和伊曲康唑.
