Abstract：
We compared 2 models of metabolic syndrome in rats: high-fat diet (58% calories) with single streptozotocin injection at a dose of 25 mg/kg and replacement of water with 20% fructose solution. The model with fructose solution did not cause the main signs of metabolic syndrome over 24 weeks: concentrations of glucose, triglycerides, cholesterol, weight, and BP did not significantly differ from the control group (standard diet). At the same time, single streptozotocin administration was followed by the development of persistent hyperglycemia, hypertriglyceridemia, hypercholesterolemia, and signs of visceral obesity. High-fat diet combined with injection of streptozotocin in a low dose can be considered a more representative model of metabolic syndrome in humans.
摘要：
我们比较了2种大鼠代谢综合征模型：高脂肪饮食（58％卡路里），单次注射25mg/kg的链脲佐菌素，并用20％果糖溶液代替水。使用果糖溶液的模型在24周内没有引起代谢综合征的主要症状：葡萄糖浓度，甘油三酯，胆固醇,体重,血压与对照组(标准饮食)无显著差异。同时,单次服用链脲佐菌素后出现持续性高血糖,高甘油三酯血症,高胆固醇血症,还有内脏肥胖的迹象.高脂饮食结合低剂量注射链脲佐菌素可以被认为是人类代谢综合征的更具代表性的模型。
