Efficacy of pegylated Graphene oxide quantum dots as a nanoconjugate sustained release metformin delivery system in in vitro insulin resistance model.

聚乙二醇化氧化石墨烯量子点作为二甲双胍纳米偶联缓释给药系统在体外胰岛素抵抗模型中的功效。

• 影响指数: 3.752
• 发表时间: 2024
• 来源期刊: PLoS One
• DOI: 10.1371/journal.pone.0307166
• PMID: 39133725
• 文章类型: Journal Article
• 中科院分区: Q2
• 方向: 综合性期刊
• 作者列表: Sarkar K,Chatterjee A,Bankura B,Bank S,Paul N,Chatterjee S,Das A,Dutta K,Chakraborty S,De S,Al-Masud AA,Khan GA,Chattopadhyay D,Das M

Mesh: Graphite / chemistry; Quantum Dots / chemistry; Metformin / administration & dosage pharmacology pharmacokinetics chemistry; Polyethylene Glycols / chemistry; Insulin Resistance; Nanoconjugates / chemistry; Delayed-Action Preparations / chemistry pharmacokinetics; Humans; Hypoglycemic Agents / administration & dosage pharmacology chemistry; Drug Delivery Systems; Diabetes Mellitus, Type 2 / drug therapy; Glucose / metabolism chemistry

Abstract

Metformin, the primary therapy for type 2 diabetes mellitus (T2DM), showed limitations such as varying absorption, rapid system clearance, required large amount, resistance, longstanding side effects. Use of Nano formulations for pharmaceuticals is emerging as a viable technique to reduce negative consequences of drug, while simultaneously attaining precise release and targeted distribution. This study developed a Polyethylene Glycol conjugated Graphene Oxide Quantum dots (GOQD-PEG) nanocomposite for the sustained release of metformin. Herein, we evaluated the effectiveness of metformin-loaded nanoconjugate in in vitro insulin resistance model. Results demonstrated drug loaded nanoconjugate successfully restored glucose uptake and reversed insulin resistance in in vitro conditions at reduced dosage compared to free metformin.

摘要

二甲双胍,2型糖尿病（T2DM）的主要治疗方法，表现出局限性，如吸收变化，快速系统清除,需要大量，阻力,长期的副作用。将纳米制剂用于药物正在成为一种可行的技术，以减少药物的负面影响，同时实现精确释放和有针对性的分配。本研究开发了聚乙二醇共轭氧化石墨烯量子点（GOQD-PEG）纳米复合材料用于二甲双胍的持续释放。在这里，我们评估了二甲双胍纳米偶联物在体外胰岛素抵抗模型中的有效性.结果表明，与游离二甲双胍相比，载药纳米缀合物在降低剂量的体外条件下成功恢复了葡萄糖摄取并逆转了胰岛素抵抗。