PDF(Pubmed)
Abstract：
BACKGROUND: Older Latino adults with HIV are at increased risk for mild cognitive impairment and earlier onset of aging-related cognitive decline. Improvements in cognitive functioning and cognitive outcomes are possible among people with HIV who adopt health promotion behaviors. However, health promotion interventions for older Latino adults with HIV have not been extensively used or widely recognized as viable treatment options. Happy Older Latinos are Active (HOLA) is a multicomponent, health promotion intervention that is uniquely tailored for older Latino adults with HIV.
OBJECTIVE: This study aims to (1) determine the feasibility and acceptability of an adapted version of HOLA aimed at improving cognitive functioning among older Latino adults with HIV; (2) explore whether HOLA will produce changes in cognitive functioning; (3) explore whether HOLA will produce changes in activity, psychosocial functioning, or biomarkers of cognition; and (4) explore whether changes in activity, psychosocial functioning or cognitive biomarkers correlate with changes in cognition, while accounting for genetic risk for dementia.
METHODS: A single-arm pilot trial with 30 Latino (aged 50 years and older) men and women with HIV was conducted to assess feasibility, acceptability, and preliminary effects on cognition. Participants were assessed at 2 time points (baseline and postintervention) on measures of neurocognitive and psychosocial functioning. In addition, blood samples were collected to determine biomarkers of cognition at baseline and postintervention. Successful recruitment was defined as meeting 100% of the targeted sample (N=30), with 20% (n=6) or less of eligible participants refusing to participate. Adequate retention was defined as 85% (n=25) or more of participants completing the postintervention assessment and acceptability was defined as 80% (n=38) or more of sessions attended by participants.
RESULTS: Participant recruitment began on February 22, 2022, and was completed on August 15, 2022. The last study visit took place on February 20, 2023. Data analysis is currently ongoing.
CONCLUSIONS: Encouraging findings from this exploratory study may provide a blueprint for scaling up the HOLA intervention to a larger cohort of older Latino adults with HIV who may be currently experiencing or are at risk for HIV-related cognitive challenges.
BACKGROUND: ClinicalTrials.gov NCT04791709; https://clinicaltrials.gov/study/NCT04791709.
UNASSIGNED: DERR1-10.2196/55507.
OBJECTIVE: This study aims to (1) determine the feasibility and acceptability of an adapted version of HOLA aimed at improving cognitive functioning among older Latino adults with HIV; (2) explore whether HOLA will produce changes in cognitive functioning; (3) explore whether HOLA will produce changes in activity, psychosocial functioning, or biomarkers of cognition; and (4) explore whether changes in activity, psychosocial functioning or cognitive biomarkers correlate with changes in cognition, while accounting for genetic risk for dementia.
METHODS: A single-arm pilot trial with 30 Latino (aged 50 years and older) men and women with HIV was conducted to assess feasibility, acceptability, and preliminary effects on cognition. Participants were assessed at 2 time points (baseline and postintervention) on measures of neurocognitive and psychosocial functioning. In addition, blood samples were collected to determine biomarkers of cognition at baseline and postintervention. Successful recruitment was defined as meeting 100% of the targeted sample (N=30), with 20% (n=6) or less of eligible participants refusing to participate. Adequate retention was defined as 85% (n=25) or more of participants completing the postintervention assessment and acceptability was defined as 80% (n=38) or more of sessions attended by participants.
RESULTS: Participant recruitment began on February 22, 2022, and was completed on August 15, 2022. The last study visit took place on February 20, 2023. Data analysis is currently ongoing.
CONCLUSIONS: Encouraging findings from this exploratory study may provide a blueprint for scaling up the HOLA intervention to a larger cohort of older Latino adults with HIV who may be currently experiencing or are at risk for HIV-related cognitive challenges.
BACKGROUND: ClinicalTrials.gov NCT04791709; https://clinicaltrials.gov/study/NCT04791709.
UNASSIGNED: DERR1-10.2196/55507.
摘要：
背景：年龄较大的拉丁裔感染HIV的成年人患轻度认知障碍的风险增加，与衰老相关的认知功能减退的发病时间较早。在采用健康促进行为的HIV感染者中，认知功能和认知结果的改善是可能的。然而,针对年龄较大的拉丁裔艾滋病毒感染者的健康促进干预措施尚未被广泛使用或被广泛认为是可行的治疗选择.快乐的老年拉丁裔活跃(HOLA)是一个多组成部分，健康促进干预措施是专门为年龄较大的拉丁裔成年人艾滋病毒。
目的：本研究旨在（1）确定HOLA的改编版本的可行性和可接受性，该版本旨在改善老年拉丁裔HIV感染者的认知功能；（2）探索HOLA是否会产生认知功能的变化；（3）探索HOLA是否会产生活动的变化，社会心理功能,或认知的生物标志物；以及(4)探索活动的变化，心理社会功能或认知生物标志物与认知变化相关，同时考虑痴呆症的遗传风险。
方法：对30名拉丁裔（50岁及以上）男性和女性进行了一项单臂试点试验，以评估其可行性。可接受性,以及对认知的初步影响。在2个时间点（基线和干预后）评估参与者的神经认知和心理社会功能。此外,在基线和干预后收集血液样本以确定认知生物标志物.成功的招聘被定义为满足100%的目标样本(N=30)，20%(n=6)或更少的合格参与者拒绝参加。充分保留被定义为85%(n=25)或更多的参与者完成干预后评估，可接受性被定义为80%(n=38)或更多的参与者参加的会议。
结果：参与者招募于2022年2月22日开始，并于2022年8月15日完成。最后一次研究访问发生在2023年2月20日。目前正在进行数据分析。
结论：来自这项探索性研究的令人鼓舞的发现可能为将HOLA干预措施扩大到更大的老年拉丁裔HIV成年人队列提供了蓝图，这些人目前可能正在经历或处于HIV相关认知挑战的风险中。
背景：ClinicalTrials.govNCT04791709;https://clinicaltrials.gov/study/NCT04791709。
■DERR1-10.2196/55507。
目的：本研究旨在（1）确定HOLA的改编版本的可行性和可接受性，该版本旨在改善老年拉丁裔HIV感染者的认知功能；（2）探索HOLA是否会产生认知功能的变化；（3）探索HOLA是否会产生活动的变化，社会心理功能,或认知的生物标志物；以及(4)探索活动的变化，心理社会功能或认知生物标志物与认知变化相关，同时考虑痴呆症的遗传风险。
方法：对30名拉丁裔（50岁及以上）男性和女性进行了一项单臂试点试验，以评估其可行性。可接受性,以及对认知的初步影响。在2个时间点（基线和干预后）评估参与者的神经认知和心理社会功能。此外,在基线和干预后收集血液样本以确定认知生物标志物.成功的招聘被定义为满足100%的目标样本(N=30)，20%(n=6)或更少的合格参与者拒绝参加。充分保留被定义为85%(n=25)或更多的参与者完成干预后评估，可接受性被定义为80%(n=38)或更多的参与者参加的会议。
结果：参与者招募于2022年2月22日开始，并于2022年8月15日完成。最后一次研究访问发生在2023年2月20日。目前正在进行数据分析。
结论：来自这项探索性研究的令人鼓舞的发现可能为将HOLA干预措施扩大到更大的老年拉丁裔HIV成年人队列提供了蓝图，这些人目前可能正在经历或处于HIV相关认知挑战的风险中。
背景：ClinicalTrials.govNCT04791709;https://clinicaltrials.gov/study/NCT04791709。
■DERR1-10.2196/55507。
