UNASSIGNED: Here, we compare important features of dioxin-like chemicals and PFAS, including the history, mechanism of action, and effective upstream regulatory strategies, with the objective of gleaning insight from the past to improve strategies for addressing PFAS.
UNASSIGNED: The differences between these two chemical classes means that regulatory strategies for dioxin-like chemicals will not be appropriate for PFAS. PFAS exert toxicity by both receptor-based and nonreceptor-based mechanisms, which complicates mixtures evaluation and stymies efforts to develop inexpensive assays that accurately capture toxicity. Furthermore, dioxin-like chemicals were unwanted byproducts, but PFAS are useful and valuable, which has led to intense resistance against efforts to restrict their production. Nonetheless, useful lessons can be drawn from dioxin-like chemicals and applied to PFAS, including eliminating nonessential production of new PFAS and proactive investment in environmental remediation to address their extraordinarily long environmental persistence. https://doi.org/10.1289/EHP14449.
■这里,我们比较二恶英类化学品和PFAS的重要特征,包括历史,作用机制,和有效的上游监管策略,目的是收集过去的洞察力,以改进解决PFAS的策略。
■这两种化学品类别之间的差异意味着二恶英类化学品的监管策略不适用于PFAS。PFAS通过基于受体和基于非受体的机制发挥毒性,这使混合物评估复杂化,并阻碍了开发准确捕获毒性的廉价检测方法的努力。此外,类似二恶英的化学物质是不需要的副产品,但是PFAS是有用和有价值的,这导致人们强烈抵制限制生产的努力。尽管如此,可以从二恶英类化学品中吸取有用的教训,并应用于PFAS,包括消除不必要的新PFAS生产和对环境修复的积极投资,以解决其超长的环境持久性。https://doi.org/10.1289/EHP14449.