PDF(Pubmed)
Abstract：
In the field of tissue engineering, 3D printed shape memory polymers (SMPs) are drawing increased interest. Understanding how these 3D printed SMPs degrade is critical for their use in the clinic, as small changes in material properties can significantly change how they behave after in vivo implantation. Degradation of 3D printed acrylated poly(glycerol-dodecanedioate) (APGD) was examined via in vitro hydrolytic, enzymatic, and in vivo subcutaneous implantation assays. Three APGD manufacturing modalities were assessed to determine differences in degradation. Material extrusion samples showed significantly larger mass and volume loss at 2 months, compared to lasercut and vat photopolymerization samples, under both enzymatic and in vivo degradation. Critically, melt transition temperatures of degraded PGD increased over time in vitro, but not in vivo. Histology of tissue surrounding APGD implants showed no significant signs of inflammation compared to controls, providing a promising outlook for use of 3D printed APGD devices in the clinic.
摘要：
在组织工程领域，3D打印的形状记忆聚合物（SMP）引起了越来越多的兴趣。了解这些3D打印的SMP如何降解对于它们在临床中的使用至关重要。因为材料特性的微小变化可以显著改变它们在体内植入后的行为。通过体外水解检查3D打印丙烯酸酯化聚（甘油-十二烷二酸酯）（APGD）的降解，酶，和体内皮下植入试验。评估了三种APGD制造方式以确定降解的差异。材料挤出样品在2个月时显示出明显更大的质量和体积损失，与激光切割和大桶光聚合样品相比，在酶和体内降解下。严重的,降解的PGD的熔融转变温度在体外随时间增加，但不是在体内。与对照组相比，APGD植入物周围组织的组织学没有明显的炎症迹象，为3D打印APGD设备在临床上的使用提供了有希望的前景。
