PDF(Pubmed)
Abstract：
Coronary calcified lesions are commonly encountered and coronary atherectomy is commonly used for lesion modification during percutaneous coronary interventions (PCI). The release of adenosine during atherectomy can result in bradyarrhythmias and aminophylline is commonly used to prevent this reaction. We identified 138 patients to evaluate the safety and efficacy of intravenous (IV) aminophylline administration prior to coronary atherectomy. A total of 159 calcified lesions were treated, and the atherectomy device was orbital atherectomy, rotational atherectomy, and both in 52 %, 42 %, and 6 %; respectively. After administration of aminophylline, 4.3 % of patients required intraprocedural insertion of a transvenous pacer (TVP), and 18.1 % of patients required administration of IV atropine. Technical success was achieved in 98.6 % of patients, and no adverse reactions to aminophylline were reported. All patients survived to discharge. In conclusion, aminophylline administration prior to coronary atherectomy was safe and effective. No adverse effects of aminophylline were seen, and the rate of bailout TVP placement was low.
摘要：
冠状动脉钙化病变是常见的，冠状动脉粥样斑块切除术通常用于经皮冠状动脉介入治疗（PCI）期间的病变修饰。在动脉粥样硬化切除术期间腺苷的释放可导致缓慢性心律失常，氨茶碱通常用于预防这种反应。我们确定了138例患者，以评估冠状动脉粥样斑块切除术前静脉（IV）氨茶碱给药的安全性和有效性。共治疗了159个钙化病灶,旋切装置是眼眶旋切术，旋磨,在52%中，42%,分别为6%和6%。服用氨茶碱后，4.3%的患者需要术中插入经静脉起搏器（TVP），18.1%的患者需要静脉注射阿托品。98.6%的患者获得了技术成功，无氨茶碱不良反应报告。所有患者均存活至出院。总之,冠状动脉粥样斑块切除术前给予氨茶碱是安全有效的.没有看到氨茶碱的不良反应，救助TVP安置率较低。
