PDF(Pubmed)
Abstract：
Schizophrenia is a severe, chronic psychiatric disorder characterized by delusions, hallucinations, cognitive impairments, and emotional dysregulation. This psychiatric illness is often resistant to treatment. This literature review aims to analyze the relationship between this complex psychological disorder and the gut microbiota found within the human body. The brain and gut are interconnected, and emerging research suggests a link between gut dysbiosis and schizophrenia. Gut dysbiosis refers to an imbalance or disruption in the composition and function of the gut microbiome. The studies comparing the gut microbiota of patients with schizophrenia to those without highlight significant differences at the phylum and genus levels, providing evidence of gut microbiome alteration. The lack of diversity of microbiota in schizophrenia patients can be altered and improved to a healthier microbiome by way of dietary intervention. Interventions that target the gut-brain axis, such as dietary probiotics or prebiotics, may help alleviate certain symptoms of schizophrenia and help improve patients\' well-being. Understanding the complex interplay between gut microbiome health and schizophrenia may allow for the development of targeted interventions that alter the gut microbiome of patients with schizophrenia and, in turn, mitigate their symptoms and improve their quality of life.
摘要：
精神分裂症是一种严重的，以妄想为特征的慢性精神疾病，幻觉,认知障碍，和情绪失调。这种精神疾病通常对治疗有抵抗力。这篇文献综述旨在分析这种复杂的心理障碍与人体内发现的肠道微生物群之间的关系。大脑和肠道是相互联系的，新兴的研究表明，肠道菌群失调和精神分裂症之间存在联系。肠道菌群失调是指肠道微生物组的组成和功能的失衡或破坏。这项研究将精神分裂症患者的肠道微生物群与那些在门和属水平上没有显着差异的研究进行了比较，提供肠道微生物组改变的证据。精神分裂症患者中微生物群多样性的缺乏可以通过饮食干预来改变和改善为更健康的微生物组。针对肠脑轴的干预措施，如膳食益生菌或益生元，可能有助于缓解精神分裂症的某些症状，并有助于改善患者的健康。了解肠道微生物组健康与精神分裂症之间复杂的相互作用，可能有助于制定有针对性的干预措施，改变精神分裂症患者的肠道微生物组，反过来,减轻他们的症状，提高他们的生活质量。
