PDF(Pubmed)
Abstract：
BACKGROUND: The gut-brain axis is a bidirectional communication network linking the gastrointestinal tract and the central nervous system via neuronal, hormonal, and antibody signaling pathways. Central to this connection is gut health, encompassing the balance and functionality of gut microbiota, which significantly impacts on mental and cognitive health. This study investigates the association between gut health and cognitive functioning in adults, highlighting the mechanisms by which gut microbiota influence brain health.
OBJECTIVE: To examine the effects of gut health on adult cognitive performance, with a focus on the processes by which gut microbiota impacts brain health.
METHODS: A quantitative cross-sectional study was conducted in Islamabad from January 2024 to April 2024, involving 140 adult participants. Data were collected using a comprehensive 16-item gut health questionnaire and the cognition self-assessment rating scale (C-SARS). The psychometric properties of these scales were assessed, and the data were analyzed using Statistical Product and Service Solutions (SPSS, v26; IBM SPSS Statistics for Windows, Armonk, NY). Analytical and descriptive statistics, including regression, chi-square, independent sample t-tests, and mean and standard deviation, were applied.
RESULTS: The study found moderate associations between gut health and cognitive performance, particularly in memory and processing speed (R² = 0.17, β = -1.9, p = 0.12 for general cognition; R² = 0.01, β = -0.98, p = 0.02 for memory; R² = 0.03, β = -0.18, p = 0.03 for processing speed). Gender and marital status differences were significant, with males exhibiting better gut health scores than females (M = 34.1, SD = 3.2 vs. M = 31.2, SD = 3.2, p = 0.00), and singles showing better cognitive performance compared to married individuals (M = 9.4, SD = 5.4 vs. M = 6.5, SD = 3.7, p = 0.03).
CONCLUSIONS: The study highlights significant associations between gut health and cognitive functions, suggesting that gut microbiota composition can influence cognitive performance. Gender and marital status differences underscore the need to consider individual differences in gut-brain axis research. Future studies should replicate these findings in larger samples and explore gut microbiota-targeted interventions for cognitive health enhancement.
OBJECTIVE: To examine the effects of gut health on adult cognitive performance, with a focus on the processes by which gut microbiota impacts brain health.
METHODS: A quantitative cross-sectional study was conducted in Islamabad from January 2024 to April 2024, involving 140 adult participants. Data were collected using a comprehensive 16-item gut health questionnaire and the cognition self-assessment rating scale (C-SARS). The psychometric properties of these scales were assessed, and the data were analyzed using Statistical Product and Service Solutions (SPSS, v26; IBM SPSS Statistics for Windows, Armonk, NY). Analytical and descriptive statistics, including regression, chi-square, independent sample t-tests, and mean and standard deviation, were applied.
RESULTS: The study found moderate associations between gut health and cognitive performance, particularly in memory and processing speed (R² = 0.17, β = -1.9, p = 0.12 for general cognition; R² = 0.01, β = -0.98, p = 0.02 for memory; R² = 0.03, β = -0.18, p = 0.03 for processing speed). Gender and marital status differences were significant, with males exhibiting better gut health scores than females (M = 34.1, SD = 3.2 vs. M = 31.2, SD = 3.2, p = 0.00), and singles showing better cognitive performance compared to married individuals (M = 9.4, SD = 5.4 vs. M = 6.5, SD = 3.7, p = 0.03).
CONCLUSIONS: The study highlights significant associations between gut health and cognitive functions, suggesting that gut microbiota composition can influence cognitive performance. Gender and marital status differences underscore the need to consider individual differences in gut-brain axis research. Future studies should replicate these findings in larger samples and explore gut microbiota-targeted interventions for cognitive health enhancement.
摘要：
背景：肠-脑轴是通过神经元连接胃肠道和中枢神经系统的双向通信网络，荷尔蒙，和抗体信号通路。这种联系的核心是肠道健康，包括肠道微生物群的平衡和功能，这对精神和认知健康有重大影响。这项研究调查了成年人肠道健康与认知功能之间的关系，强调肠道微生物群影响大脑健康的机制。
目的：为了研究肠道健康对成人认知能力的影响，重点关注肠道微生物群影响大脑健康的过程。
方法：于2024年1月至2024年4月在伊斯兰堡进行了一项定量横断面研究，涉及140名成年参与者。使用全面的16项肠道健康问卷和认知自评估评定量表（C-SARS）收集数据。评估了这些量表的心理测量特性，并使用统计产品和服务解决方案(SPSS，v26;IBMSPSSStatisticsforWindows,Armonk,NY).分析和描述性统计，包括回归，卡方,独立样本t检验，以及平均值和标准偏差，被应用了。
结果：研究发现，肠道健康与认知能力之间存在中度关联，特别是在记忆和处理速度方面（对于一般认知，R²=0.17，β=-1.9，p=0.12；对于记忆，R²=0.01，β=-0.98，p=0.02；对于处理速度，R²=0.03，β=-0.18，p=0.03）。性别和婚姻状况差异显著,男性的肠道健康评分优于女性(M=34.1，SD=3.2与M=31.2，SD=3.2，p=0.00），与已婚人士相比，单身人士表现出更好的认知表现(M=9.4，SD=5.4与M=6.5，SD=3.7，p=0.03）。
结论：该研究强调了肠道健康和认知功能之间的显著关联，这表明肠道菌群组成可以影响认知表现。性别和婚姻状况差异强调了在肠-脑轴研究中需要考虑个体差异。未来的研究应该在更大的样本中复制这些发现，并探索针对肠道微生物群的干预措施以增强认知健康。
目的：为了研究肠道健康对成人认知能力的影响，重点关注肠道微生物群影响大脑健康的过程。
方法：于2024年1月至2024年4月在伊斯兰堡进行了一项定量横断面研究，涉及140名成年参与者。使用全面的16项肠道健康问卷和认知自评估评定量表（C-SARS）收集数据。评估了这些量表的心理测量特性，并使用统计产品和服务解决方案(SPSS，v26;IBMSPSSStatisticsforWindows,Armonk,NY).分析和描述性统计，包括回归，卡方,独立样本t检验，以及平均值和标准偏差，被应用了。
结果：研究发现，肠道健康与认知能力之间存在中度关联，特别是在记忆和处理速度方面（对于一般认知，R²=0.17，β=-1.9，p=0.12；对于记忆，R²=0.01，β=-0.98，p=0.02；对于处理速度，R²=0.03，β=-0.18，p=0.03）。性别和婚姻状况差异显著,男性的肠道健康评分优于女性(M=34.1，SD=3.2与M=31.2，SD=3.2，p=0.00），与已婚人士相比，单身人士表现出更好的认知表现(M=9.4，SD=5.4与M=6.5，SD=3.7，p=0.03）。
结论：该研究强调了肠道健康和认知功能之间的显著关联，这表明肠道菌群组成可以影响认知表现。性别和婚姻状况差异强调了在肠-脑轴研究中需要考虑个体差异。未来的研究应该在更大的样本中复制这些发现，并探索针对肠道微生物群的干预措施以增强认知健康。
