关键词: Anticancer Fermented foods Metabolites Microbiome Probiotics

来  源:   DOI:10.1007/s10068-024-01638-5   PDF(Pubmed)

Abstract:
One of the greatest threats to global health is cancer. Probiotic foods have been shown to have therapeutic promise in the management of cancer, even though traditional treatments such as radiation therapy, chemotherapy, and surgery are still essential. The generation of anticarcinogenic compounds, immune system stimulation, and gut microbiota regulation are a few ways that probiotics when taken in sufficient quantities, might help health. The purpose of this review is to examine the therapeutic potential of probiotic foods in the management of cancer. Research suggests that certain strains of probiotics have anticancer effects by preventing the growth of cancer cells, triggering apoptosis, and reducing angiogenesis in new tumors. Probiotics have shown promise in mitigating treatment-related adverse effects, such as diarrhea, mucositis, and immunosuppression caused by chemotherapy, improving the general quality of life for cancer patients. However, there are several factors, such as patient-specific features, cancer subtype, and probiotic strain type and dosage, which affect how effective probiotic therapies are in managing cancer. More research is necessary to find the long-term safety and efficacy characteristics of probiotics as well as to clarify the best ways to incorporate them into current cancer treatment methods.
UNASSIGNED: Graphical representation showing the role of probiotic foods in cancer management.
摘要:
全球健康面临的最大威胁之一是癌症。益生菌食品已被证明在治疗癌症方面具有治疗前景,即使传统的治疗方法,如放射治疗,化疗,手术仍然是必不可少的。抗癌化合物的产生,免疫系统刺激,和肠道微生物群调节是益生菌摄入足够量时的几种方式,可能有助于健康。这篇综述的目的是研究益生菌食品在癌症治疗中的治疗潜力。研究表明,某些益生菌菌株通过阻止癌细胞的生长而具有抗癌作用,触发细胞凋亡,减少新肿瘤的血管生成。益生菌在减轻治疗相关的不良反应方面表现出了希望,比如腹泻,粘膜炎,化疗引起的免疫抑制,改善癌症患者的总体生活质量。然而,有几个因素,例如特定于患者的特征,癌症亚型,益生菌菌株类型和剂量,这影响了益生菌疗法在治疗癌症方面的有效性。需要更多的研究来发现益生菌的长期安全性和有效性特征,并阐明将其纳入当前癌症治疗方法的最佳方法。
显示益生菌食品在癌症管理中的作用的图形表示。
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