PDF(Pubmed)
Abstract：
UNASSIGNED: The location and type of a tumor influence the prognosis of lung cancer. Primary Central Lung Tumors (PCLTs) are correlated with poor prognoses and certain histologic types. This study aimed to present a comprehensive exploration of clinical and bronchoscopic assessments for diagnosing the histopathology types of PCLTs and identified the factors associated with certain histologic types.
UNASSIGNED: This was an observational cross-sectional study of PCLTs, defined as tumors in direct contact with hilar structures or located within the inner two-thirds of the hemithorax. We gathered demographic and clinical data, as well as data on bronchoscopy assessment and histopathology type. Tumor stage, symptoms of superior vena cava syndrome, and enlargement of lymph nodes in the paratracheal and subcarinal regions were also documented.
UNASSIGNED: Of the 895 patients, 37.87% had primary lung tumors, with 17.76% classified as PCLTs. Notably, PCLT cases exhibited a higher proportion of stage III (28.9% vs. 18.3%; p = 0.03) and Squamous Cell Carcinoma (SCC) histopathology (37.1% vs. 17.2%; p = 0.00) compared with non-PCLT cases. Bronchoscopic findings in PCLTs revealed a predilection for central airway masses (25.2%) and compressive distal airway stenosis (25.2%). Subgroup analysis of 159 PCLT cases identified 37.10% as SCC. Multivariate analysis underscored that intraluminal masses predict central SCC (odds ratio 2.075, 95% confidence interval 1.07-3.99; p = 0.028).
UNASSIGNED: The proportion of stage III, SCC histopathological type, and intraluminal lesions was higher in patients with PCLT than in non-PCLT cases. The presence of intraluminal lesions can predict the histopathological type of SCC in patients with PCLTs.
UNASSIGNED: This was an observational cross-sectional study of PCLTs, defined as tumors in direct contact with hilar structures or located within the inner two-thirds of the hemithorax. We gathered demographic and clinical data, as well as data on bronchoscopy assessment and histopathology type. Tumor stage, symptoms of superior vena cava syndrome, and enlargement of lymph nodes in the paratracheal and subcarinal regions were also documented.
UNASSIGNED: Of the 895 patients, 37.87% had primary lung tumors, with 17.76% classified as PCLTs. Notably, PCLT cases exhibited a higher proportion of stage III (28.9% vs. 18.3%; p = 0.03) and Squamous Cell Carcinoma (SCC) histopathology (37.1% vs. 17.2%; p = 0.00) compared with non-PCLT cases. Bronchoscopic findings in PCLTs revealed a predilection for central airway masses (25.2%) and compressive distal airway stenosis (25.2%). Subgroup analysis of 159 PCLT cases identified 37.10% as SCC. Multivariate analysis underscored that intraluminal masses predict central SCC (odds ratio 2.075, 95% confidence interval 1.07-3.99; p = 0.028).
UNASSIGNED: The proportion of stage III, SCC histopathological type, and intraluminal lesions was higher in patients with PCLT than in non-PCLT cases. The presence of intraluminal lesions can predict the histopathological type of SCC in patients with PCLTs.
摘要：
■肿瘤的位置和类型影响肺癌的预后。原发性中央型肺肿瘤（PCLTs）与不良预后和某些组织学类型相关。本研究旨在全面探索临床和支气管镜评估以诊断PCLT的组织病理学类型，并确定与某些组织学类型相关的因素。
■这是一项观察性横断面研究，定义为与肺门结构直接接触或位于半胸部内部三分之二内的肿瘤。我们收集了人口统计学和临床数据，以及支气管镜检查评估和组织病理学类型的数据。肿瘤分期,上腔静脉综合征的症状，并且还记录了气管旁和隆突下区域的淋巴结肿大。
■在895名患者中，37.87%有原发性肺肿瘤，17.76%被归类为PCLT。值得注意的是,PCLT病例表现出更高的III期比例(28.9%vs.18.3%；p=0.03）和鳞状细胞癌（SCC）组织病理学（37.1%vs.17.2%；p=0.00）与非PCLT病例相比。PCLTs的支气管镜检查结果显示中央气道肿块（25.2％）和远端气道压缩性狭窄（25.2％）。159例PCLT病例的亚组分析确定37.10%为SCC。多变量分析强调管腔内肿块可预测中央SCC（比值比2.075，95％置信区间1.07-3.99；p=0.028）。
■第三阶段的比例，SCC组织病理学类型,PCLT患者的管腔内病变高于非PCLT患者。腔内病变的存在可以预测PCLT患者SCC的组织病理学类型。
■这是一项观察性横断面研究，定义为与肺门结构直接接触或位于半胸部内部三分之二内的肿瘤。我们收集了人口统计学和临床数据，以及支气管镜检查评估和组织病理学类型的数据。肿瘤分期,上腔静脉综合征的症状，并且还记录了气管旁和隆突下区域的淋巴结肿大。
■在895名患者中，37.87%有原发性肺肿瘤，17.76%被归类为PCLT。值得注意的是,PCLT病例表现出更高的III期比例(28.9%vs.18.3%；p=0.03）和鳞状细胞癌（SCC）组织病理学（37.1%vs.17.2%；p=0.00）与非PCLT病例相比。PCLTs的支气管镜检查结果显示中央气道肿块（25.2％）和远端气道压缩性狭窄（25.2％）。159例PCLT病例的亚组分析确定37.10%为SCC。多变量分析强调管腔内肿块可预测中央SCC（比值比2.075，95％置信区间1.07-3.99；p=0.028）。
■第三阶段的比例，SCC组织病理学类型,PCLT患者的管腔内病变高于非PCLT患者。腔内病变的存在可以预测PCLT患者SCC的组织病理学类型。
