PDF(Pubmed)
Abstract：
While the extracellular matrix (ECM) has long been recognized for its structural contributions, anchoring cells for adhesion, providing mechanical support, and maintaining tissue integrity, recent efforts have elucidated its dynamic, reciprocal, and diverse properties on angiogenesis. The ECM modulates angiogenic signaling and mechanical transduction, influences the extent and degree of receptor activation, controls cellular behaviors, and serves as a reservoir for bioactive macromolecules. Collectively, these factors guide the formation, maturation, and stabilization of a functional vascular network. This review aims to shed light on the versatile roles of the ECM in angiogenesis, transcending its traditional functions as a mere structural material. We will explore its engagement and synergy in signaling modulation, interactions with various angiogenic factors, and highlight its importance in both health and disease. By capturing the essence of the ECM\'s diverse functionalities, we highlight the significance in the broader context of vascular biology, enabling the design of novel biomaterials to engineer vascularized tissues and their potential therapeutic implications.
摘要：
虽然细胞外基质（ECM）长期以来一直被认为是其结构贡献，锚定粘附细胞，提供机械支持，保持组织的完整性,最近的努力阐明了它的动态，倒数，和血管生成的不同特性。ECM调节血管生成信号和机械转导，影响受体激活的程度和程度，控制细胞行为，并作为生物活性大分子的储库。总的来说，这些因素指导形成，成熟,和功能性血管网络的稳定。这篇综述旨在阐明ECM在血管生成中的多功能作用。超越其作为单纯结构材料的传统功能。我们将探索其在信号调制中的参与和协同作用，与各种血管生成因子的相互作用，并强调其在健康和疾病中的重要性。通过捕捉ECM不同功能的本质，我们强调了血管生物学在更广泛背景下的重要性，使新型生物材料的设计能够工程化血管化组织及其潜在的治疗意义。
