PDF(Pubmed)
Abstract：
OBJECTIVE: Alzheimer\'s disease is a progressive neurodegenerative disorder characterized by cognitive decline, behavioral changes, and functional impairments. Apathy, a common symptom in Alzheimer\'s disease, refers to a lack of motivation, interest, and emotional responsiveness. It can significantly impact patients\' quality of life and increase caregiver burden. This study aimed to determine the effects of a diversified rehabilitation program combined with donepezil on apathy, cognitive function, and family caregiver burden of Alzheimer\'s disease patients.
METHODS: A total of 105 Alzheimer\'s disease patients treated at our hospital between January 2020 and January 2023 were selected and analyzed retrospectively. They were assigned to the control group (n = 50) or the observation group (n = 55). The two groups did not differ in terms of general data such as age and sex. All patients were treated with donepezil orally. The control group was given routine nursing, whereas the observation group was given a diversified rehabilitation program intervention, including cognitive training and emotional support. The Hasegawa\'s dementia scale, mini-mental state examination, and Montreal cognitive assessment scale were adopted to evaluate the cognitive function of the two groups before and after treatment. A caregiver burden scale, the Zarit Burden Interview (ZBI) and the Apathy Evaluation Scale Informant version (AES-I) were used to evaluate the caregiver burden and apathy of the two groups.
RESULTS: A significantly higher overall response rate to treatment was found in the observation group (94.55%) than in the control group (80.00%) (p = 0.024). After treatment, scores on the Hasegawa\'s dementia scale, mini-mental state examination, and Montreal cognitive assessment scale of the two groups increased to varying degrees, with greater increases in the observation group than in the control group (p < 0.05). The ZBI and AES-I scores of the two groups decreased to different degrees after treatment, with greater decreases in the observation group than in the control group (p < 0.05).
CONCLUSIONS: A diversified rehabilitation program combined with donepezil can substantially alleviate the apathy of Alzheimer\'s disease patients, improve their cognitive function, and reduce the burden on their families.
METHODS: A total of 105 Alzheimer\'s disease patients treated at our hospital between January 2020 and January 2023 were selected and analyzed retrospectively. They were assigned to the control group (n = 50) or the observation group (n = 55). The two groups did not differ in terms of general data such as age and sex. All patients were treated with donepezil orally. The control group was given routine nursing, whereas the observation group was given a diversified rehabilitation program intervention, including cognitive training and emotional support. The Hasegawa\'s dementia scale, mini-mental state examination, and Montreal cognitive assessment scale were adopted to evaluate the cognitive function of the two groups before and after treatment. A caregiver burden scale, the Zarit Burden Interview (ZBI) and the Apathy Evaluation Scale Informant version (AES-I) were used to evaluate the caregiver burden and apathy of the two groups.
RESULTS: A significantly higher overall response rate to treatment was found in the observation group (94.55%) than in the control group (80.00%) (p = 0.024). After treatment, scores on the Hasegawa\'s dementia scale, mini-mental state examination, and Montreal cognitive assessment scale of the two groups increased to varying degrees, with greater increases in the observation group than in the control group (p < 0.05). The ZBI and AES-I scores of the two groups decreased to different degrees after treatment, with greater decreases in the observation group than in the control group (p < 0.05).
CONCLUSIONS: A diversified rehabilitation program combined with donepezil can substantially alleviate the apathy of Alzheimer\'s disease patients, improve their cognitive function, and reduce the burden on their families.
摘要：
目的：阿尔茨海默病是一种以认知功能下降为特征的进行性神经退行性疾病，行为改变,和功能障碍。冷漠,阿尔茨海默病的常见症状，指的是缺乏动力，兴趣,和情绪反应。它可以显著影响患者的生活质量和增加照顾者的负担。本研究旨在确定多元化康复计划联合多奈哌齐对冷漠的影响。认知功能,阿尔茨海默病患者的家庭照顾负担。
方法：选取我院2020年1月至2023年1月收治的105例阿尔茨海默病患者进行回顾性分析。将其分为对照组(n=50)和观察组(n=55)。两组在年龄、性别等一般资料上无差异。所有患者均口服多奈哌齐。对照组给予常规护理,而观察组给予多元化康复方案干预,包括认知训练和情感支持。长谷川痴呆症量表，小型精神状态检查，采用蒙特利尔认知评估量表对两组患者治疗前后的认知功能进行评估。护理人员负担量表，使用Zarit负担访谈(ZBI)和冷漠评估量表资料者版(AES-I)评估两组的照顾者负担和冷漠.
结果：观察组治疗总有效率（94.55%）明显高于对照组（80.00%）（p=0.024）。治疗后,长谷川痴呆症量表上的分数，小型精神状态检查，两组的蒙特利尔认知评估量表均有不同程度的提高,观察组增加幅度大于对照组(p<0.05)。两组治疗后ZBI和AES-I评分均有不同程度的下降,观察组下降幅度大于对照组(p<0.05)。
结论：多元化康复方案联合多奈哌齐可显著缓解阿尔茨海默病患者的冷漠情绪。提高他们的认知功能，减轻家庭负担。
方法：选取我院2020年1月至2023年1月收治的105例阿尔茨海默病患者进行回顾性分析。将其分为对照组(n=50)和观察组(n=55)。两组在年龄、性别等一般资料上无差异。所有患者均口服多奈哌齐。对照组给予常规护理,而观察组给予多元化康复方案干预,包括认知训练和情感支持。长谷川痴呆症量表，小型精神状态检查，采用蒙特利尔认知评估量表对两组患者治疗前后的认知功能进行评估。护理人员负担量表，使用Zarit负担访谈(ZBI)和冷漠评估量表资料者版(AES-I)评估两组的照顾者负担和冷漠.
结果：观察组治疗总有效率（94.55%）明显高于对照组（80.00%）（p=0.024）。治疗后,长谷川痴呆症量表上的分数，小型精神状态检查，两组的蒙特利尔认知评估量表均有不同程度的提高,观察组增加幅度大于对照组(p<0.05)。两组治疗后ZBI和AES-I评分均有不同程度的下降,观察组下降幅度大于对照组(p<0.05)。
结论：多元化康复方案联合多奈哌齐可显著缓解阿尔茨海默病患者的冷漠情绪。提高他们的认知功能，减轻家庭负担。
