PDF(Pubmed)
Abstract：
Transposable elements make up substantial proportions of eukaryotic genomes and many are thought to be remnants of ancient viral infections. Current research has begun to highlight the role transposable elements can play in the immune system response to infections. However, most of our knowledge about transposable element expression during infection is limited by the specific host and pathogen factors from each study, making it difficult to compare studies and develop broader patterns regarding the role of transposable elements during infection. Here, we use the tools and resources available in the model, Drosophila melanogaster, to analyze multiple gene expression datasets of flies subject to bacterial, fungal, and viral infections. We analyzed differences in pathogen species, host genotype, host tissue, and sex to understand how these factors impact transposable element expression during infection. Our results highlight both shared and unique transposable element expression patterns between pathogens and suggest a larger effect of pathogen factors over host factors for influencing transposable element expression.
摘要：
转座因子占真核生物基因组的很大比例，许多被认为是古代病毒感染的残留物。目前的研究已经开始强调转座因子在免疫系统对感染的反应中的作用。然而,我们对感染过程中转座因子表达的大部分知识都受到来自每个研究的特定宿主和病原体因子的限制，这使得很难对转座因子在感染过程中的作用进行比较研究和开发更广泛的模式。这里,我们使用模型中可用的工具和资源，黑腹果蝇,分析受细菌影响的果蝇的多个基因表达数据集，真菌,和病毒感染。我们分析了病原体种类的差异，宿主基因型，宿主组织，和性别，以了解这些因素如何影响感染期间的转座因子表达。我们的结果突出了病原体之间共享和独特的转座因子表达模式，并表明病原体因子对宿主因子影响转座因子表达的作用更大。
