{Reference Type}: Journal Article
{Title}: Pathogen infection alters the gene expression landscape of transposable elements in Drosophila melanogaster.
{Author}: Mostoufi SL;Singh ND;
{Journal}: G3 (Bethesda)
{Volume}: 14
{Issue}: 9
{Year}: 2024 Sep 4
{Factor}: 3.542
{DOI}: 10.1093/g3journal/jkae171
{Abstract}: Transposable elements make up substantial proportions of eukaryotic genomes and many are thought to be remnants of ancient viral infections. Current research has begun to highlight the role transposable elements can play in the immune system response to infections. However, most of our knowledge about transposable element expression during infection is limited by the specific host and pathogen factors from each study, making it difficult to compare studies and develop broader patterns regarding the role of transposable elements during infection. Here, we use the tools and resources available in the model, Drosophila melanogaster, to analyze multiple gene expression datasets of flies subject to bacterial, fungal, and viral infections. We analyzed differences in pathogen species, host genotype, host tissue, and sex to understand how these factors impact transposable element expression during infection. Our results highlight both shared and unique transposable element expression patterns between pathogens and suggest a larger effect of pathogen factors over host factors for influencing transposable element expression.