Abstract：
BACKGROUND: Dietary patterns are associated with dementia risk, but the underlying molecular mechanisms are largely unknown.
METHODS: We used RNA sequencing data from post mortem prefrontal cortex tissue and annual cognitive evaluations from 1204 participants in the Religious Orders Study and Memory and Aging Project. We identified a transcriptomic profile correlated with the MIND diet (Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay) among 482 individuals who completed ante mortem food frequency questionnaires; and examined its associations with cognitive health in the remaining 722 participants.
RESULTS: We identified a transcriptomic profile, consisting of 50 genes, correlated with the MIND diet score (p = 0.001). Each standard deviation increase in the transcriptomic profile score was associated with a slower annual rate of decline in global cognition (β = 0.011, p = 0.003) and lower odds of dementia (odds ratio = 0.76, p = 0.0002). Expressions of several genes (including TCIM and IGSF5) appeared to mediate the association between MIND diet and dementia.
CONCLUSIONS: A brain transcriptomic profile for healthy diets revealed novel genes potentially associated with cognitive health.
CONCLUSIONS: Why healthy dietary patterns are associated with lower dementia risk are unknown. We integrated dietary, brain transcriptomic, and cognitive data in older adults. Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet intake is correlated with a specific brain transcriptomic profile. This brain transcriptomic profile score is associated with better cognitive health. More data are needed to elucidate the causality and functionality of identified genes.
METHODS: We used RNA sequencing data from post mortem prefrontal cortex tissue and annual cognitive evaluations from 1204 participants in the Religious Orders Study and Memory and Aging Project. We identified a transcriptomic profile correlated with the MIND diet (Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay) among 482 individuals who completed ante mortem food frequency questionnaires; and examined its associations with cognitive health in the remaining 722 participants.
RESULTS: We identified a transcriptomic profile, consisting of 50 genes, correlated with the MIND diet score (p = 0.001). Each standard deviation increase in the transcriptomic profile score was associated with a slower annual rate of decline in global cognition (β = 0.011, p = 0.003) and lower odds of dementia (odds ratio = 0.76, p = 0.0002). Expressions of several genes (including TCIM and IGSF5) appeared to mediate the association between MIND diet and dementia.
CONCLUSIONS: A brain transcriptomic profile for healthy diets revealed novel genes potentially associated with cognitive health.
CONCLUSIONS: Why healthy dietary patterns are associated with lower dementia risk are unknown. We integrated dietary, brain transcriptomic, and cognitive data in older adults. Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet intake is correlated with a specific brain transcriptomic profile. This brain transcriptomic profile score is associated with better cognitive health. More data are needed to elucidate the causality and functionality of identified genes.
摘要：
背景：饮食模式与痴呆风险相关，但是潜在的分子机制在很大程度上是未知的。
方法：我们使用了来自死后前额叶皮质组织的RNA测序数据和来自宗教秩序研究和记忆与衰老项目1204名参与者的年度认知评估。我们在482名完成了死前食物频率问卷的个体中确定了与MIND饮食（停止高血压干预神经退行性延迟的地中海饮食方法）相关的转录组学概况；并在其余722名参与者中检查了其与认知健康的关联。
结果：我们确定了一个转录组，由50个基因组成，与MIND饮食评分相关(p=0.001)。转录组概况得分的每个标准差增加与全球认知的年度下降速度较慢（β=0.011，p=0.003）和痴呆的几率较低（比值比=0.76，p=0.0002）相关。几种基因（包括TCIM和IGSF5）的表达似乎介导了MIND饮食与痴呆之间的关联。
结论：健康饮食的脑转录组学图谱揭示了与认知健康潜在相关的新基因。
结论：为什么健康的饮食模式与较低的痴呆风险相关尚不清楚。我们整合了饮食，大脑转录组，和老年人的认知数据。地中海饮食方法停止高血压干预神经退行性延迟（MIND）饮食摄入与特定的脑转录组相关。这种脑转录组概况评分与更好的认知健康相关。需要更多的数据来阐明已鉴定基因的因果关系和功能。
方法：我们使用了来自死后前额叶皮质组织的RNA测序数据和来自宗教秩序研究和记忆与衰老项目1204名参与者的年度认知评估。我们在482名完成了死前食物频率问卷的个体中确定了与MIND饮食（停止高血压干预神经退行性延迟的地中海饮食方法）相关的转录组学概况；并在其余722名参与者中检查了其与认知健康的关联。
结果：我们确定了一个转录组，由50个基因组成，与MIND饮食评分相关(p=0.001)。转录组概况得分的每个标准差增加与全球认知的年度下降速度较慢（β=0.011，p=0.003）和痴呆的几率较低（比值比=0.76，p=0.0002）相关。几种基因（包括TCIM和IGSF5）的表达似乎介导了MIND饮食与痴呆之间的关联。
结论：健康饮食的脑转录组学图谱揭示了与认知健康潜在相关的新基因。
结论：为什么健康的饮食模式与较低的痴呆风险相关尚不清楚。我们整合了饮食，大脑转录组，和老年人的认知数据。地中海饮食方法停止高血压干预神经退行性延迟（MIND）饮食摄入与特定的脑转录组相关。这种脑转录组概况评分与更好的认知健康相关。需要更多的数据来阐明已鉴定基因的因果关系和功能。
