METHODS: We used RNA sequencing data from post mortem prefrontal cortex tissue and annual cognitive evaluations from 1204 participants in the Religious Orders Study and Memory and Aging Project. We identified a transcriptomic profile correlated with the MIND diet (Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay) among 482 individuals who completed ante mortem food frequency questionnaires; and examined its associations with cognitive health in the remaining 722 participants.
RESULTS: We identified a transcriptomic profile, consisting of 50 genes, correlated with the MIND diet score (p = 0.001). Each standard deviation increase in the transcriptomic profile score was associated with a slower annual rate of decline in global cognition (β = 0.011, p = 0.003) and lower odds of dementia (odds ratio = 0.76, p = 0.0002). Expressions of several genes (including TCIM and IGSF5) appeared to mediate the association between MIND diet and dementia.
CONCLUSIONS: A brain transcriptomic profile for healthy diets revealed novel genes potentially associated with cognitive health.
CONCLUSIONS: Why healthy dietary patterns are associated with lower dementia risk are unknown. We integrated dietary, brain transcriptomic, and cognitive data in older adults. Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet intake is correlated with a specific brain transcriptomic profile. This brain transcriptomic profile score is associated with better cognitive health. More data are needed to elucidate the causality and functionality of identified genes.
方法:我们使用了来自死后前额叶皮质组织的RNA测序数据和来自宗教秩序研究和记忆与衰老项目1204名参与者的年度认知评估。我们在482名完成了死前食物频率问卷的个体中确定了与MIND饮食(停止高血压干预神经退行性延迟的地中海饮食方法)相关的转录组学概况;并在其余722名参与者中检查了其与认知健康的关联。
结果:我们确定了一个转录组,由50个基因组成,与MIND饮食评分相关(p=0.001)。转录组概况得分的每个标准差增加与全球认知的年度下降速度较慢(β=0.011,p=0.003)和痴呆的几率较低(比值比=0.76,p=0.0002)相关。几种基因(包括TCIM和IGSF5)的表达似乎介导了MIND饮食与痴呆之间的关联。
结论:健康饮食的脑转录组学图谱揭示了与认知健康潜在相关的新基因。
结论:为什么健康的饮食模式与较低的痴呆风险相关尚不清楚。我们整合了饮食,大脑转录组,和老年人的认知数据。地中海饮食方法停止高血压干预神经退行性延迟(MIND)饮食摄入与特定的脑转录组相关。这种脑转录组概况评分与更好的认知健康相关。需要更多的数据来阐明已鉴定基因的因果关系和功能。