%0 Journal Article
%T The MIND diet, brain transcriptomic alterations, and dementia.
%A Li J
%A Capuano AW
%A Agarwal P
%A Arvanitakis Z
%A Wang Y
%A De Jager PL
%A Schneider JA
%A Tasaki S
%A de Paiva Lopes K
%A Hu FB
%A Bennett DA
%A Liang L
%A Grodstein F
%J Alzheimers Dement
%V 0
%N 0
%D 2024 Aug 11
%M 39129336
%F 16.655
%R 10.1002/alz.14062
%X <B>BACKGROUND: </B>Dietary patterns are associated with dementia risk, but the underlying molecular mechanisms are largely unknown.<BR><B>METHODS: </B>We used RNA sequencing data from post mortem prefrontal cortex tissue and annual cognitive evaluations from 1204 participants in the Religious Orders Study and Memory and Aging Project. We identified a transcriptomic profile correlated with the MIND diet (Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay) among 482 individuals who completed ante mortem food frequency questionnaires; and examined its associations with cognitive health in the remaining 722 participants.<BR><B>RESULTS: </B>We identified a transcriptomic profile, consisting of 50 genes, correlated with the MIND diet score (p = 0.001). Each standard deviation increase in the transcriptomic profile score was associated with a slower annual rate of decline in global cognition (β = 0.011, p = 0.003) and lower odds of dementia (odds ratio = 0.76, p = 0.0002). Expressions of several genes (including TCIM and IGSF5) appeared to mediate the association between MIND diet and dementia.<BR><B>CONCLUSIONS: </B>A brain transcriptomic profile for healthy diets revealed novel genes potentially associated with cognitive health.<BR><B>CONCLUSIONS: </B>Why healthy dietary patterns are associated with lower dementia risk are unknown. We integrated dietary, brain transcriptomic, and cognitive data in older adults. Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet intake is correlated with a specific brain transcriptomic profile. This brain transcriptomic profile score is associated with better cognitive health. More data are needed to elucidate the causality and functionality of identified genes.