Abstract：
BACKGROUND: Frontotemporal dementia (FTD) can be phenotypically divided into behavioral variant FTD (bvFTD), nonfluent variant primary progressive aphasia (nfvPPA), and semantic variant PPA (svPPA). However, the neural underpinnings of this phenotypic heterogeneity remain elusive.
METHODS: Cortical morphology, white matter hyperintensities (WMH), diffusion tensor image analysis along the perivascular space (DTI-ALPS), and their interrelationships were assessed in subtypes of FTD. Neuroimaging-transcriptional analyses on the regional cortical morphological deviances among subtypes were also performed.
RESULTS: Changes in cortical thickness, surface area, gyrification, WMH, and DTI-ALPS were subtype-specific in FTD. The three morphologic indices are related to whole-brain WMH volume and cognitive performance, while cortical thickness is related to DTI-ALPS. Neuroimaging-transcriptional analyses identified key biological pathways linked to the formation and/or spread of TDP-43/tau pathologies.
CONCLUSIONS: We found subtype-specific changes in cortical morphology, WMH, and glymphatic function in FTD. Our findings have the potential to contribute to the development of personalized predictions and treatment strategies for this disorder.
CONCLUSIONS: Cortical morphologic changes, white matter hyperintensities (WMH), and glymphatic dysfunction are subtype-specific. Cortical morphologic changes, WMH, and glymphatic dysfunction are inter-correlated. Cortical morphologic changes and WMH burden contribute to cognitive impairments.
METHODS: Cortical morphology, white matter hyperintensities (WMH), diffusion tensor image analysis along the perivascular space (DTI-ALPS), and their interrelationships were assessed in subtypes of FTD. Neuroimaging-transcriptional analyses on the regional cortical morphological deviances among subtypes were also performed.
RESULTS: Changes in cortical thickness, surface area, gyrification, WMH, and DTI-ALPS were subtype-specific in FTD. The three morphologic indices are related to whole-brain WMH volume and cognitive performance, while cortical thickness is related to DTI-ALPS. Neuroimaging-transcriptional analyses identified key biological pathways linked to the formation and/or spread of TDP-43/tau pathologies.
CONCLUSIONS: We found subtype-specific changes in cortical morphology, WMH, and glymphatic function in FTD. Our findings have the potential to contribute to the development of personalized predictions and treatment strategies for this disorder.
CONCLUSIONS: Cortical morphologic changes, white matter hyperintensities (WMH), and glymphatic dysfunction are subtype-specific. Cortical morphologic changes, WMH, and glymphatic dysfunction are inter-correlated. Cortical morphologic changes and WMH burden contribute to cognitive impairments.
摘要：
背景：额颞叶痴呆（FTD）可以在表型上分为行为变异FTD（bvFTD），非流利型原发性进行性失语症（nfvPPA），和语义变异PPA(svPPA)。然而,这种表型异质性的神经基础仍然难以捉摸.
方法：皮质形态学，白质高强度（WMH），沿血管周围空间的扩散张量图像分析（DTI-ALPS），并在FTD亚型中评估了它们之间的相互关系。还对亚型之间的区域皮质形态偏差进行了神经影像学转录分析。
结果：皮质厚度的变化，表面积,陀螺，WMH,DTI-ALPS在FTD中具有亚型特异性。这三个形态学指标与全脑WMH体积和认知能力有关，而皮质厚度与DTI-ALPS有关。神经成像-转录分析确定了与TDP-43/tau病理的形成和/或传播相关的关键生物学途径。
结论：我们发现皮质形态的亚型特异性变化，WMH,和FTD中的淋巴功能。我们的发现有可能有助于这种疾病的个性化预测和治疗策略的发展。
结论：皮质形态变化，白质高强度（WMH），而类淋巴功能障碍是亚型特异性的。皮质形态变化,WMH,和淋巴功能障碍是相互关联的。皮质形态学改变和WMH负担导致认知障碍。
方法：皮质形态学，白质高强度（WMH），沿血管周围空间的扩散张量图像分析（DTI-ALPS），并在FTD亚型中评估了它们之间的相互关系。还对亚型之间的区域皮质形态偏差进行了神经影像学转录分析。
结果：皮质厚度的变化，表面积,陀螺，WMH,DTI-ALPS在FTD中具有亚型特异性。这三个形态学指标与全脑WMH体积和认知能力有关，而皮质厚度与DTI-ALPS有关。神经成像-转录分析确定了与TDP-43/tau病理的形成和/或传播相关的关键生物学途径。
结论：我们发现皮质形态的亚型特异性变化，WMH,和FTD中的淋巴功能。我们的发现有可能有助于这种疾病的个性化预测和治疗策略的发展。
结论：皮质形态变化，白质高强度（WMH），而类淋巴功能障碍是亚型特异性的。皮质形态变化,WMH,和淋巴功能障碍是相互关联的。皮质形态学改变和WMH负担导致认知障碍。
