Abstract：
OBJECTIVE: To develop and validate the Oral Lichen Planus-Disease Activity Scale (OLP-DAS) for assessing overall disease activity of OLP.
METHODS: The OLP-DAS was created by refining the Thongprasom criteria, incorporating inputs from the literature and expert review, and integrating pain assessment. Content validity was evaluated in a virtual meeting with 8 Oral Medicine specialists. Reliability and validity of the final version were examined. Seventeen OLP subjects were assessed for disease activity by 10 investigators using the OLP-DAS, Oral Disease Severity Score (ODSS), OLP-Investigator Global Assessment (OLP-IGA), and Reticular-Erythema-Ulcerative (REU) scale. Convergent validity was assessed by rating 160 OLP subjects using the OLP-DAS, ODSS, and OLP-IGA. Inter-rater and intra-rater reliability, along with convergent validity, were analyzed using intraclass correlation coefficients (ICCs) and Spearman\'s rank correlation coefficients (rs).
RESULTS: The final OLP-DAS achieved excellent content validity indices. Inter-rater and intra-rater ICCs for total OLP-DAS scores were 0.93 and 0.96, respectively. Total OLP-DAS scores exhibited strong positive correlations with the ODSS and OLP-IGA (rs = 0.94 and rs = 0.76; P < 0.001, respectively). The OLP Severity Index (OLP-SI), a component of the OLP-DAS, showed very strong positive correlations with OLP disease activity parameters of the ODSS (rs = 0.90; P < 0.001).
CONCLUSIONS: The OLP-DAS is a valid and reliable clinician-reported outcome measure (CROM) for evaluating OLP disease activity.
CONCLUSIONS: The OLP-DAS, as a standardized CROM for OLP, is valuable for both routine clinical assessments and research applications.
METHODS: The OLP-DAS was created by refining the Thongprasom criteria, incorporating inputs from the literature and expert review, and integrating pain assessment. Content validity was evaluated in a virtual meeting with 8 Oral Medicine specialists. Reliability and validity of the final version were examined. Seventeen OLP subjects were assessed for disease activity by 10 investigators using the OLP-DAS, Oral Disease Severity Score (ODSS), OLP-Investigator Global Assessment (OLP-IGA), and Reticular-Erythema-Ulcerative (REU) scale. Convergent validity was assessed by rating 160 OLP subjects using the OLP-DAS, ODSS, and OLP-IGA. Inter-rater and intra-rater reliability, along with convergent validity, were analyzed using intraclass correlation coefficients (ICCs) and Spearman\'s rank correlation coefficients (rs).
RESULTS: The final OLP-DAS achieved excellent content validity indices. Inter-rater and intra-rater ICCs for total OLP-DAS scores were 0.93 and 0.96, respectively. Total OLP-DAS scores exhibited strong positive correlations with the ODSS and OLP-IGA (rs = 0.94 and rs = 0.76; P < 0.001, respectively). The OLP Severity Index (OLP-SI), a component of the OLP-DAS, showed very strong positive correlations with OLP disease activity parameters of the ODSS (rs = 0.90; P < 0.001).
CONCLUSIONS: The OLP-DAS is a valid and reliable clinician-reported outcome measure (CROM) for evaluating OLP disease activity.
CONCLUSIONS: The OLP-DAS, as a standardized CROM for OLP, is valuable for both routine clinical assessments and research applications.
摘要：
目的：开发并验证口腔扁平苔藓疾病活动度量表（OLP-DAS），以评估OLP的总体疾病活动度。
方法：OLP-DAS是通过完善Thongprasom标准创建的，结合文献和专家审查的投入，并整合疼痛评估。在与8位口腔医学专家的虚拟会议中评估了内容的有效性。检验了最终版本的信度和效度。10名研究者使用OLP-DAS评估了17名OLP受试者的疾病活动性，口腔疾病严重程度评分（ODSS），OLP-研究者全球评估（OLP-IGA），网状红斑-溃疡性（REU）量表。通过使用OLP-DAS对160名OLP受试者进行评级来评估收敛有效性，ODSS,OLP-IGA。评价者间和评价者间的可靠性，随着收敛有效性，使用组内相关系数(ICC)和斯皮尔曼秩相关系数(rs)进行分析。
结果：最终的OLP-DAS取得了优异的内容效度指数。OLP-DAS总分的评分者间和评分者内ICC分别为0.93和0.96。OLP-DAS总评分与ODSS和OLP-IGA表现出强正相关(rs=0.94和rs=0.76;P<0.001,分别)。OLP严重程度指数(OLP-SI)OLP-DAS的一个组成部分，与ODSS的OLP疾病活动参数呈非常强的正相关（rs=0.90；P<0.001）。
结论：OLP-DAS是评估OLP疾病活动性的有效和可靠的临床医生报告的结果测量（CROM）。
结论：OLP-DAS，作为OLP的标准化CROM，对于常规临床评估和研究应用都很有价值。
方法：OLP-DAS是通过完善Thongprasom标准创建的，结合文献和专家审查的投入，并整合疼痛评估。在与8位口腔医学专家的虚拟会议中评估了内容的有效性。检验了最终版本的信度和效度。10名研究者使用OLP-DAS评估了17名OLP受试者的疾病活动性，口腔疾病严重程度评分（ODSS），OLP-研究者全球评估（OLP-IGA），网状红斑-溃疡性（REU）量表。通过使用OLP-DAS对160名OLP受试者进行评级来评估收敛有效性，ODSS,OLP-IGA。评价者间和评价者间的可靠性，随着收敛有效性，使用组内相关系数(ICC)和斯皮尔曼秩相关系数(rs)进行分析。
结果：最终的OLP-DAS取得了优异的内容效度指数。OLP-DAS总分的评分者间和评分者内ICC分别为0.93和0.96。OLP-DAS总评分与ODSS和OLP-IGA表现出强正相关(rs=0.94和rs=0.76;P<0.001,分别)。OLP严重程度指数(OLP-SI)OLP-DAS的一个组成部分，与ODSS的OLP疾病活动参数呈非常强的正相关（rs=0.90；P<0.001）。
结论：OLP-DAS是评估OLP疾病活动性的有效和可靠的临床医生报告的结果测量（CROM）。
结论：OLP-DAS，作为OLP的标准化CROM，对于常规临床评估和研究应用都很有价值。
