%0 Journal Article
%T Development and validation of the Oral Lichen Planus-Disease Activity Scale: a novel tool for comprehensive clinical assessment.
%A Somsak P
%A Piboonratanakit P
%A Pongsiriwet S
%A Sappayatosok K
%A Sarideechaigul W
%A Taebunpakul P
%A Pimolbutr K
%A Ayudhya CCN
%A Pengpis N
%A Wiriyakijja P
%J Clin Oral Investig
%V 28
%N 9
%D 2024 Aug 12
%M 39129032
%F 3.606
%R 10.1007/s00784-024-05875-0
%X <B>OBJECTIVE: </B>To develop and validate the Oral Lichen Planus-Disease Activity Scale (OLP-DAS) for assessing overall disease activity of OLP.<BR><B>METHODS: </B>The OLP-DAS was created by refining the Thongprasom criteria, incorporating inputs from the literature and expert review, and integrating pain assessment. Content validity was evaluated in a virtual meeting with 8 Oral Medicine specialists. Reliability and validity of the final version were examined. Seventeen OLP subjects were assessed for disease activity by 10 investigators using the OLP-DAS, Oral Disease Severity Score (ODSS), OLP-Investigator Global Assessment (OLP-IGA), and Reticular-Erythema-Ulcerative (REU) scale. Convergent validity was assessed by rating 160 OLP subjects using the OLP-DAS, ODSS, and OLP-IGA. Inter-rater and intra-rater reliability, along with convergent validity, were analyzed using intraclass correlation coefficients (ICCs) and Spearman's rank correlation coefficients (rs).<BR><B>RESULTS: </B>The final OLP-DAS achieved excellent content validity indices. Inter-rater and intra-rater ICCs for total OLP-DAS scores were 0.93 and 0.96, respectively. Total OLP-DAS scores exhibited strong positive correlations with the ODSS and OLP-IGA (rs = 0.94 and rs = 0.76; P < 0.001, respectively). The OLP Severity Index (OLP-SI), a component of the OLP-DAS, showed very strong positive correlations with OLP disease activity parameters of the ODSS (rs = 0.90; P < 0.001).<BR><B>CONCLUSIONS: </B>The OLP-DAS is a valid and reliable clinician-reported outcome measure (CROM) for evaluating OLP disease activity.<BR><B>CONCLUSIONS: </B>The OLP-DAS, as a standardized CROM for OLP, is valuable for both routine clinical assessments and research applications.