Abstract：
UNASSIGNED: Parkinson\'s disease (PD) involves the progressive loss of dopaminergic neurons and the accumulation of α-synuclein. Elevated cholesterol levels may exacerbate α-synuclein aggregation, potentially contributing to PD. This study investigates the link between lipid profiles and PD severity, as well as cognitive functions in patients, aiming to inform pathogenesis and management strategies.
UNASSIGNED: Data from 250 PD patients and 100 healthy controls were analyzed. Serum cholesterol levels were compared with disease severity using Unified Parkinson\'s Disease Rating Scale (UPDRS) and modified Hoehn & Yahr Rating Scale (mH&Y). Mini-Mental State Examination (MMSE) assessed cognitive functions.
UNASSIGNED: Of the participants, 45.4% were female, 54.6% male, with a mean age of 69.09 ± 11.13 years. Mean UPDRS score was 52.34 ± 26.32, mH&Y was 2.28 ± 0.91. Patients had significantly higher HDL levels (47.92 ± 11.63) than controls (45.40 ± 13.89) (p = 0.024). HDL levels were significantly higher in patients with cognitive impairment than in patients with cognitive normal (p = 0.004). On the contrary, triglyceride levels were significantly lower in those with cognitive impairment compared to those with cognitively normal (p = 0.005). Multivariate logistic regression showed being male associated with 3.796 times higher risk of illness, and HDL is associated with 1.030 times increased illness risk.
UNASSIGNED: High HDL levels and male gender particularly increase the risk of Parkinson\'s disease. Additionally, HDL and triglyceride levels affect the cognition of PD patients. Further studies on the impact of cholesterol metabolism on the pathogenesis of PD could contribute to identifying effective treatment targets.
UNASSIGNED: Data from 250 PD patients and 100 healthy controls were analyzed. Serum cholesterol levels were compared with disease severity using Unified Parkinson\'s Disease Rating Scale (UPDRS) and modified Hoehn & Yahr Rating Scale (mH&Y). Mini-Mental State Examination (MMSE) assessed cognitive functions.
UNASSIGNED: Of the participants, 45.4% were female, 54.6% male, with a mean age of 69.09 ± 11.13 years. Mean UPDRS score was 52.34 ± 26.32, mH&Y was 2.28 ± 0.91. Patients had significantly higher HDL levels (47.92 ± 11.63) than controls (45.40 ± 13.89) (p = 0.024). HDL levels were significantly higher in patients with cognitive impairment than in patients with cognitive normal (p = 0.004). On the contrary, triglyceride levels were significantly lower in those with cognitive impairment compared to those with cognitively normal (p = 0.005). Multivariate logistic regression showed being male associated with 3.796 times higher risk of illness, and HDL is associated with 1.030 times increased illness risk.
UNASSIGNED: High HDL levels and male gender particularly increase the risk of Parkinson\'s disease. Additionally, HDL and triglyceride levels affect the cognition of PD patients. Further studies on the impact of cholesterol metabolism on the pathogenesis of PD could contribute to identifying effective treatment targets.
摘要：
■帕金森病（PD）涉及多巴胺能神经元的进行性丢失和α-突触核蛋白的积累。胆固醇水平升高可能会加剧α-突触核蛋白聚集，可能有助于PD。这项研究调查了血脂与PD严重程度之间的联系，以及患者的认知功能，旨在告知发病机制和管理策略。
■分析了来自250名PD患者和100名健康对照的数据。使用统一帕金森病评定量表(UPDRS)和改良Hoehn&Yahr评定量表(mH&Y)比较血清胆固醇水平与疾病严重程度。简易精神状态检查(MMSE)评估认知功能。
■在参与者中，45.4%是女性，54.6%男性,平均年龄69.09±11.13岁。平均UPDRS评分为52.34±26.32，mH&Y为2.28±0.91。患者的HDL水平（47.92±11.63）明显高于对照组（45.40±13.89）（p=0.024）。认知障碍患者的HDL水平明显高于认知正常患者（p=0.004）。相反,与认知正常的患者相比,认知功能障碍患者的甘油三酯水平显著降低(p=0.005).多因素logistic回归分析显示，男性患病风险高3.796倍，HDL与1.030倍的疾病风险增加相关。
■高密度脂蛋白水平和男性特别增加帕金森病的风险。此外,HDL和甘油三酯水平影响PD患者的认知功能。进一步研究胆固醇代谢对PD发病机制的影响可能有助于确定有效的治疗靶点。
■分析了来自250名PD患者和100名健康对照的数据。使用统一帕金森病评定量表(UPDRS)和改良Hoehn&Yahr评定量表(mH&Y)比较血清胆固醇水平与疾病严重程度。简易精神状态检查(MMSE)评估认知功能。
■在参与者中，45.4%是女性，54.6%男性,平均年龄69.09±11.13岁。平均UPDRS评分为52.34±26.32，mH&Y为2.28±0.91。患者的HDL水平（47.92±11.63）明显高于对照组（45.40±13.89）（p=0.024）。认知障碍患者的HDL水平明显高于认知正常患者（p=0.004）。相反,与认知正常的患者相比,认知功能障碍患者的甘油三酯水平显著降低(p=0.005).多因素logistic回归分析显示，男性患病风险高3.796倍，HDL与1.030倍的疾病风险增加相关。
■高密度脂蛋白水平和男性特别增加帕金森病的风险。此外,HDL和甘油三酯水平影响PD患者的认知功能。进一步研究胆固醇代谢对PD发病机制的影响可能有助于确定有效的治疗靶点。
