Abstract：
Behçet\'s Disease (BD) is an intricate medical puzzle, captivating researchers with its enigmatic pathogenesis. This complex ailment, distinguished by recurrent mouth and genital lesions, eye irritation, and skin injuries, presents a substantial obstacle to therapeutic research. This review explores the complex interaction of microRNAs (miRNAs) with BD, highlighting their crucial involvement in the disease\'s pathophysiology. miRNAs, recognized for regulatory influence in diverse biological processes, hold a pivotal position in the molecular mechanisms of autoimmune diseases, such as BD. The exploration begins with examining miRNA biogenic pathways and functions, establishing a foundational understanding of their regulatory mechanisms. Shifting to the molecular landscape governing BD, the review highlights miRNA-mediated impacts on critical signaling pathways like Notch, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and protein kinase B (AKT)/mammalian target of rapamycin (mTOR), offering insights into intricate pathophysiological mechanisms. Dissecting the immunological landscape reveals the profound influence of miRNAs on BD, shedding light on the intricate modulation of immune responses and offering novel perspectives on disease etiology and progression. Beyond molecular intricacies, the review explores the clinical relevance of miRNAs in BD, emphasizing their potential as diagnostic and prognostic indicators. The discussion extends to the promising realm of miRNA-based therapeutic interventions, highlighting their potential in alleviating symptoms and altering disease progression. This comprehensive review, serving as a valuable resource for researchers, clinicians, and stakeholders, aims to decipher the intricate molecular tapestry of BD and explore the therapeutic potential of miRNAs.
摘要：
Behçet疾病（BD）是一个复杂的医学难题，迷人的研究人员以其神秘的发病机理。这种复杂的疾病，以复发性口腔和生殖器病变为特征，眼睛刺激,和皮肤损伤，对治疗研究提出了重大障碍。这篇综述探讨了microRNAs（miRNAs）与BD的复杂相互作用，强调他们在疾病的病理生理学中的关键参与。miRNA,被公认为在不同生物过程中的监管影响，在自身免疫性疾病的分子机制中占有举足轻重的地位，例如BD。探索从研究miRNA生物通路和功能开始，建立对他们监管机制的基本理解。转向控制BD的分子景观，这篇综述强调了miRNA介导的对Notch等关键信号通路的影响，核因子κ-活化B细胞的轻链增强子（NF-κB），和蛋白激酶B（AKT）/哺乳动物雷帕霉素靶蛋白（mTOR），提供对复杂病理生理机制的见解。剖析免疫学景观揭示了miRNA对BD的深刻影响，阐明免疫反应的复杂调节，并为疾病的病因和进展提供新的观点。除了分子的复杂性，这篇综述探讨了miRNA在BD中的临床意义，强调它们作为诊断和预后指标的潜力。讨论扩展到基于miRNA的治疗干预的有希望的领域，强调它们在缓解症状和改变疾病进展方面的潜力。这次全面审查，作为研究人员的宝贵资源，临床医生,和利益相关者，旨在破译BD复杂的分子挂毯，探索miRNAs的治疗潜力。
