Abstract：
Coccidiosis is a highly significant disease in domestic animals due to its global distribution and economic impact. The occurrence of oxidative stress (OS) and the acute phase response (APR) play crucial roles in the development of coccidiosis, thereby contributing to the pathogenicity of coccidia. A range of triggers including parasitic infection, can induce the APR. This response encompasses a set of hormonal and metabolic changes to restore body stability and improve the body\'s healing capabilities. Ovine coccidiosis has the potential to cause OS, which can be prevented and treated through the use of dietary additives. By including Curcuma longa in the diets of infected sheep, it is possible to reduce lipid peroxidation (LPO) and nitric oxide (NO) production, while simultaneously improving serum antioxidant capacity and interleukin-10 (IL-10) levels. Caprine coccidiosis can activate the APR. Research indicated that goats suffering from coccidiosis exhibited elevated concentrations of malondialdehyde (MDA) and total homocysteine, along with reduced levels of some enzymes such as superoxide dismutase (SOD) and glutathione reductase (GR), as well as decreased levels of zinc (Zn), manganese (Mn), selenium (Se), vitamin C, and total antioxidant capacity (TAC). Bovine coccidiosis is linked to elevated MDA concentrations and reduced serum glutathione (GSH) and TAC levels. Eimeria can induce OS and inflammatory damage in infected birds by releasing pro-inflammatory mediators from cells, resulting in a significant increase in CAT and SOD activity, lipid peroxidation and damage to the intestinal epithelium. To promote the antioxidant system of infected birds, some herbal food additives such as grape seed proanthocyanidine extract, Curcuma longa and Rumex nervosus leaf extract, can be used. Research on the APR in birds is not as extensive as in ruminants. Currently, there is a lack of studies on the occurrence of OS and APR in camels, horses, dogs, and cats with coccidiosis.
摘要：
球虫病由于其全球分布和经济影响而在家畜中是一种非常重要的疾病。氧化应激(OS)和急性期反应(APR)的发生在球虫病的发生发展中起着至关重要的作用,从而有助于球虫的致病性。一系列的触发因素包括寄生虫感染,可以诱导APR。这种反应包括一系列荷尔蒙和代谢变化，以恢复身体稳定性并提高身体的康复能力。绵羊球虫病有可能导致OS，可以通过使用膳食添加剂来预防和治疗。通过在受感染绵羊的饮食中加入姜黄，有可能减少脂质过氧化（LPO）和一氧化氮（NO）的产生，同时提高血清抗氧化能力和白细胞介素-10（IL-10）水平。山羊球虫病可以激活APR。研究表明，患有球虫病的山羊表现出丙二醛（MDA）和总同型半胱氨酸的浓度升高，随着一些酶如超氧化物歧化酶（SOD）和谷胱甘肽还原酶（GR）的水平降低，以及锌(Zn)水平的降低，锰(Mn),硒(Se),维生素C,和总抗氧化能力(TAC)。牛球虫病与MDA浓度升高以及血清谷胱甘肽（GSH）和TAC水平降低有关。艾美球虫可以通过从细胞中释放促炎介质来诱导感染鸟类的OS和炎症损伤，导致CAT和SOD活性显着增加，脂质过氧化和肠上皮损伤。为了促进受感染鸟类的抗氧化系统，一些草药食品添加剂，如葡萄籽原花青素提取物，姜黄和乳香叶提取物，可以使用。对鸟类APR的研究不如反刍动物广泛。目前,缺乏对骆驼OS和APR发生的研究，马,狗,还有患有球虫病的猫.
