PDF(Pubmed)
Abstract：
BACKGROUND: Misuse and overuse of antibiotics comprise leading causes of antimicrobial resistance. The study aims to assess the pattern of antibiotic prescription among primary healthcare general practitioners in the South Batinah Governorate of Oman.
METHODS: A cross-sectional study of 600 antibiotic prescriptions issued in the South Batinah Governorate in 2019 was conducted to verify the triggering diagnoses and determine the appropriateness of the prescribed antibiotic. Logistic regression analysis was used to determine the association between predictors and inappropriate use.
RESULTS: Respiratory infections accounted for 62% of antibiotic prescriptions, of which 92.2% were inappropriately prescribed. Extended-spectrum antibiotics were inappropriately prescribed in 33.3% of cystitis cases, while 14.3% of gastroenteritis received incorrect spectrum of antibiotics. Amoxicillin represented 46.2% of antibiotic prescriptions, of which 84.4% were unnecessarily prescribed. Lower inappropriate antibiotic prescribing rate was linked to patients ≥ 18 years (OR = 0.46, 95% CI: [0.26, 0.82]), those who underwent laboratory tests (OR = 0.22, 95% CI: [0.12, 0.39]), and consultations at health centers (OR = 0.44, 95% CI: [0.24, 0.79]). Arabic-speaking physicians were more likely to prescribe antibiotics inappropriately.
CONCLUSIONS: Inappropriate antibiotic prescription was frequently observed in mild respiratory infections and associated with specific patient and physician characteristics. Appropriateness of antibiotic prescriptions issued can be improved through enhanced testing capacities as well as implementation of physician and community awareness campaigns.
METHODS: A cross-sectional study of 600 antibiotic prescriptions issued in the South Batinah Governorate in 2019 was conducted to verify the triggering diagnoses and determine the appropriateness of the prescribed antibiotic. Logistic regression analysis was used to determine the association between predictors and inappropriate use.
RESULTS: Respiratory infections accounted for 62% of antibiotic prescriptions, of which 92.2% were inappropriately prescribed. Extended-spectrum antibiotics were inappropriately prescribed in 33.3% of cystitis cases, while 14.3% of gastroenteritis received incorrect spectrum of antibiotics. Amoxicillin represented 46.2% of antibiotic prescriptions, of which 84.4% were unnecessarily prescribed. Lower inappropriate antibiotic prescribing rate was linked to patients ≥ 18 years (OR = 0.46, 95% CI: [0.26, 0.82]), those who underwent laboratory tests (OR = 0.22, 95% CI: [0.12, 0.39]), and consultations at health centers (OR = 0.44, 95% CI: [0.24, 0.79]). Arabic-speaking physicians were more likely to prescribe antibiotics inappropriately.
CONCLUSIONS: Inappropriate antibiotic prescription was frequently observed in mild respiratory infections and associated with specific patient and physician characteristics. Appropriateness of antibiotic prescriptions issued can be improved through enhanced testing capacities as well as implementation of physician and community awareness campaigns.
摘要：
背景：抗生素的滥用和过度使用是抗生素耐药性的主要原因。该研究旨在评估阿曼南巴蒂纳省初级保健全科医生的抗生素处方模式。
方法：对2019年在南巴蒂纳省发行的600种抗生素处方进行了横断面研究，以验证触发诊断并确定处方抗生素的适当性。使用Logistic回归分析来确定预测因子与不当使用之间的关联。
结果：呼吸道感染占抗生素处方的62％，其中92.2%的处方不当。在33.3%的膀胱炎病例中，超广谱抗生素的处方不当，而14.3％的胃肠炎接受了不正确的抗生素谱。阿莫西林占抗生素处方的46.2%，其中84.4%是不必要的处方。较低的不适当抗生素处方率与≥18岁的患者相关（OR=0.46，95％CI：[0.26，0.82]），那些接受实验室检查的人(OR=0.22，95%CI：[0.12，0.39])，和医疗中心的会诊(OR=0.44，95%CI：[0.24，0.79])。讲阿拉伯语的医生更有可能不适当地开抗生素。
结论：在轻度呼吸道感染中经常观察到不适当的抗生素处方，并与特定的患者和医师特征相关。可以通过增强测试能力以及实施医师和社区宣传运动来改善发布的抗生素处方的适当性。
方法：对2019年在南巴蒂纳省发行的600种抗生素处方进行了横断面研究，以验证触发诊断并确定处方抗生素的适当性。使用Logistic回归分析来确定预测因子与不当使用之间的关联。
结果：呼吸道感染占抗生素处方的62％，其中92.2%的处方不当。在33.3%的膀胱炎病例中，超广谱抗生素的处方不当，而14.3％的胃肠炎接受了不正确的抗生素谱。阿莫西林占抗生素处方的46.2%，其中84.4%是不必要的处方。较低的不适当抗生素处方率与≥18岁的患者相关（OR=0.46，95％CI：[0.26，0.82]），那些接受实验室检查的人(OR=0.22，95%CI：[0.12，0.39])，和医疗中心的会诊(OR=0.44，95%CI：[0.24，0.79])。讲阿拉伯语的医生更有可能不适当地开抗生素。
结论：在轻度呼吸道感染中经常观察到不适当的抗生素处方，并与特定的患者和医师特征相关。可以通过增强测试能力以及实施医师和社区宣传运动来改善发布的抗生素处方的适当性。
