Abstract：
Inbred mouse strains KK.Cg-a/a and KK.Cg-Ay/a known as genetic models of type 2 diabetes mellitus significantly surpassed the control strain C57BL/6J in the body weight, relative weight of extractable fat, and basal blood glucose levels. Real-timePCR of fecal samples from KK.Cg-a/a and KK.Cg-Ay/a mice revealed dysbiosis typical of type 2 diabetes mellitus in humans and animals. Long-term intragastric administration of a suspension of Hafnia alvei bacteria had no effect on the above morphometric and biochemical parameters. At the same time, recovery of the Bacteroides spp. population in KK.Cg-Ay/a mice and a decrease in the number of Bifidobacterium spp. in KK.Cg-a/a mice were observed. The possibility of therapeutic use of the probiotic based on H. alvei is discussed.
摘要：
近交系小鼠品系KK。Cg-a/a和KK。被称为2型糖尿病遗传模型的Cg-Ay/a在体重上显著超过对照菌株C57BL/6J,可提取脂肪的相对重量，和基础血糖水平。来自KK的粪便样品的实时PCR。Cg-a/a和KK。Cg-Ay/a小鼠揭示了人类和动物中典型的2型糖尿病的生态失调。长期灌胃Hafnia肺泡细菌悬浮液对上述形态计量学和生化参数没有影响。同时,拟杆菌的回收。KK人口。Cg-Ay/a小鼠和双歧杆菌数量减少。在KK。观察Cg-a/a小鼠。讨论了基于嗜血杆菌的益生菌的治疗用途的可能性。
