{Reference Type}: Journal Article
{Title}: Effect of Hafnia alvei on Morphophysiologic Parameters and Gut Microbiota of Mice with Inherited Type 2 Diabetes Mellitus.
{Author}: Zolotarev VA;Murovets VO;Novikova NS;Ermolenko EI;Sepp AL;Khropycheva RP;
{Journal}: Bull Exp Biol Med
{Volume}: 177
{Issue}: 3
{Year}: 2024 Jul 10
{Factor}: 0.737
{DOI}: 10.1007/s10517-024-06180-2
{Abstract}: Inbred mouse strains KK.Cg-a/a and KK.Cg-Ay/a known as genetic models of type 2 diabetes mellitus significantly surpassed the control strain C57BL/6J in the body weight, relative weight of extractable fat, and basal blood glucose levels. Real-timePCR of fecal samples from KK.Cg-a/a and KK.Cg-Ay/a mice revealed dysbiosis typical of type 2 diabetes mellitus in humans and animals. Long-term intragastric administration of a suspension of Hafnia alvei bacteria had no effect on the above morphometric and biochemical parameters. At the same time, recovery of the Bacteroides spp. population in KK.Cg-Ay/a mice and a decrease in the number of Bifidobacterium spp. in KK.Cg-a/a mice were observed. The possibility of therapeutic use of the probiotic based on H. alvei is discussed.