Abstract：
The extensive application of plastics in different sectors such as packaging, building, textiles, consumer products, and several industries has increased in recent years. Emerging data have confirmed that plastic wastes and segregates are problematic issues in aquatic and terrestrial ecosystems. The decomposition of plastic particles (PPs) leads to the release of microplastics (MPs) and nanoplastics (NPs) into the surrounding environment and entry of these particles will be problematic in unicellular and multicellular creatures. It was suggested that PPs can easily cross all biological barriers and reach different organs, especially the cardiovascular system, with the potential to modulate several molecular pathways. It is postulated that the direct interaction of PPs with cellular and subcellular components induces genotoxicity and cytotoxicity within the cardiovascular system. Meanwhile, being inert carriers, PPs can intensify the toxicity of other contaminants inside the cardiovascular system. Here, in this review article, several underlying mechanisms related to PP toxicity in the cardiovascular system were discussed in detail.
摘要：
塑料在包装等不同领域的广泛应用，建筑,纺织品,消费品,近年来，一些行业有所增加。新兴数据证实，塑料废物和隔离是水生和陆地生态系统中的问题。塑料颗粒(PP)的分解导致微塑料(MPs)和纳米塑料(NPs)释放到周围环境中,并且这些颗粒的进入在单细胞和多细胞生物中将是有问题的。有人认为，PPs可以轻松地跨越所有生物屏障并到达不同的器官，尤其是心血管系统，具有调节几种分子途径的潜力。假定PPs与细胞和亚细胞组分的直接相互作用在心血管系统内诱导遗传毒性和细胞毒性。同时,作为惰性载体，PPs可以增强心血管系统内其他污染物的毒性。这里,在这篇评论文章中，本文详细讨论了与心血管系统PP毒性相关的几种潜在机制.
