PDF(Pubmed)
Abstract：
Alzheimer\'s disease (AD) is a condition in the brain that is marked by a gradual and ongoing reduction in memory, thought, and the ability to perform simple tasks. AD has a poor prognosis but no cure yet. Therefore, the need for novel models to study its pathogenesis and therapeutic strategies is evident, as the brain poorly recovers after injury and neurodegenerative diseases and can neither replace dead neurons nor reinnervate target structures. Recently, mesenchymal stem cells (MSCs), particularly those from the human olfactory mucous membrane referred to as the olfactory ecto-MSCs (OE-MSCs), have emerged as a potential avenue to explore in modeling AD and developing therapeutics for the disease due to their lifelong regeneration potency and facile accessibility. This review provides a comprehensive summary of the current literature on isolating OE-MSCs and delves into whether they could be reliable models for studying AD pathogenesis. It also explores whether healthy individual-derived OE-MSCs could be therapeutic agents for the disease. Despite being a promising tool in modeling and developing therapies for AD, some significant issues remain, which are also discussed in the review.
摘要：
阿尔茨海默病（AD）是大脑中的一种疾病，其特征是记忆逐渐减少，思想,以及执行简单任务的能力。AD预后不良，但尚未治愈。因此,需要新的模型来研究其发病机制和治疗策略是显而易见的，因为大脑在受伤和神经退行性疾病后恢复不佳，既不能取代死亡的神经元，也不能恢复靶结构。最近,间充质干细胞(MSCs),特别是那些来自人类嗅觉粘膜的称为嗅外MSCs（OE-MSCs），由于其终生的再生效力和容易的可及性，已成为模拟AD和开发该疾病疗法的潜在途径。这篇综述提供了关于分离OE-MSCs的现有文献的全面总结，并探讨了它们是否可以作为研究AD发病机制的可靠模型。它还探讨了健康的个体来源的OE-MSC是否可以成为该疾病的治疗剂。尽管在AD的建模和开发治疗方面是一个有前途的工具，一些重大问题仍然存在，审查中也讨论了这些问题。
