PDF(Pubmed)
Abstract：
Lipid metabolism is a critical component in preserving homeostasis and health, and lipids are significant chemicals involved in energy metabolism in living things. With the growing interest in lipid metabolism in recent years, an increasing number of studies have demonstrated the close relationship between abnormalities in lipid metabolism and the development of numerous human diseases, including cancer, cardiovascular, neurological, and endocrine system diseases. Thus, understanding how aberrant lipid metabolism contributes to the development of related diseases and how it works offers a theoretical foundation for treating and preventing related human diseases as well as new avenues for the targeted treatment of related diseases. Therefore, we discuss the processes of aberrant lipid metabolism in various human diseases in this review, including diseases of the cardiovascular system, neurodegenerative diseases, endocrine system diseases (such as obesity and type 2 diabetes mellitus), and other diseases including cancer.
摘要：
脂质代谢是维持体内平衡和健康的关键组成部分，和脂质是参与生物能量代谢的重要化学物质。近年来随着人们对脂质代谢的兴趣日益浓厚,越来越多的研究表明，脂质代谢异常与许多人类疾病的发展密切相关，包括癌症,心血管,神经学,和内分泌系统疾病。因此，了解异常脂质代谢如何促进相关疾病的发展及其作用机制，为治疗和预防相关疾病提供了理论基础，也为相关疾病的靶向治疗提供了新的途径。因此,在这篇综述中，我们讨论了各种人类疾病中异常脂质代谢的过程，包括心血管系统疾病，神经退行性疾病，内分泌系统疾病（如肥胖和2型糖尿病），和其他疾病，包括癌症。
