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Abstract：
To analyze the role of interleukin IL-17A and IL-10 polymorphisms in susceptibility to juvenile idiopathic arthritis (JIA), 98 Finnish children and adolescents with JIA were studied. Data from the 1000 Genomes Project, consisting of 99 healthy Finns, served as the controls. The patients were analyzed for four IL-17A and three IL-10 gene-promoter polymorphisms, and the serum IL-17A, IL-17F, IL-10, and IL-6 levels were determined. The IL-17A rs8193036 variant genotypes (CT/CC) were more common among the patients than controls, especially in those with polyarthritis (OR 1.93, 95% CI 1.11-3.36; p = 0.020). IL-17A rs2275913 minor allele A was more common in patients (OR 1.45, 95% Cl 1.08-1.94; p = 0.014) and especially among patients with oligoarthritis and polyarthritis than the controls (OR 1.61, 95%CI 1.06-2.43; p = 0.024). Carriers of the IL-17A rs4711998 variant genotype (AG/AA) had higher serum IL-17A levels than those with genotype GG. However, carriers of the variant genotypes of IL-17A rs9395767 and rs4711998 appeared to have higher IL-17F levels than those carrying wildtype. IL-10 rs1800896 variant genotypes (TC/CC) were more abundant in patients than in the controls (OR 1.97, 95%CI 1.06-3.70; p = 0.042). Carriers of the IL-10 rs1800896 variant genotypes had lower serum levels of IL-17F than those with wildtype. These data provide preliminary evidence of the roles of IL-17 and IL-10 in the pathogenesis of JIA and its subtypes in the Finnish population. However, the results should be interpreted with caution, as the number of subjects included in this study was limited.
摘要：
分析白细胞介素-IL-17A和IL-10基因多态性在幼年特发性关节炎(JIA)易感性中的作用,研究了98名患有JIA的芬兰儿童和青少年。1000基因组计划的数据,由99个健康的芬兰人组成，作为控制。分析患者的4种IL-17A和3种IL-10基因启动子多态性,和血清IL-17A,IL-17F,测定IL-10和IL-6水平。IL-17Ars8193036变异基因型（CT/CC）在患者中比对照组更常见，尤其是多关节炎患者(OR1.93,95%CI1.11-3.36;p=0.020)。IL-17Ars2275913次要等位基因A在患者中更为常见（OR1.45，95％Cl1.08-1.94；p=0.014），尤其是在少关节炎和多关节炎患者中比对照组更常见（OR1.61，95CI1.06-2.43；p=0.024）。IL-17Ars4711998变异基因型（AG/AA）的携带者的血清IL-17A水平高于GG基因型的携带者。然而,IL-17Ars9395767和rs4711998的变异基因型的携带者似乎比携带野生型的携带者具有更高的IL-17F水平。IL-10rs1800896变异基因型（TC/CC）在患者中的含量高于对照组（OR1.97，95CI1.06-3.70；p=0.042）。IL-10rs1800896变异基因型的携带者的IL-17F血清水平低于野生型携带者。这些数据为IL-17和IL-10在芬兰人群中JIA及其亚型的发病机理中的作用提供了初步证据。然而,结果应谨慎解释，因为纳入本研究的受试者数量有限.
