关键词: cancer therapies development history of photodynamic therapy in vitro in vivo nanotechnology photodynamic therapy photosensitizers

Mesh : Photochemotherapy / methods Humans Photosensitizing Agents / therapeutic use Neoplasms / drug therapy Animals Bacterial Infections / drug therapy

来  源:   DOI:10.3390/ijms25158258   PDF(Pubmed)

Abstract:
Over the past decades, medicine has made enormous progress, revolutionized by modern technologies and innovative therapeutic approaches. One of the most exciting branches of these developments is photodynamic therapy (PDT). Using a combination of light of a specific wavelength and specially designed photosensitizing substances, PDT offers new perspectives in the fight against cancer, bacterial infections, and other diseases that are resistant to traditional treatment methods. In today\'s world, where there is a growing problem of drug resistance, the search for alternative therapies is becoming more and more urgent. Imagine that we could destroy cancer cells or bacteria using light, without the need to use strong chemicals or antibiotics. This is what PDT promises. By activating photosensitizers using appropriately adjusted light, this therapy can induce the death of cancer or bacterial cells while minimizing damage to surrounding healthy tissues. In this work, we will explore this fascinating method, discovering its mechanisms of action, clinical applications, and development prospects. We will also analyze the latest research and patient testimonies to understand the potential of PDT for the future of medicine.
摘要:
在过去的几十年里,医学取得了巨大的进步,革命性的现代技术和创新的治疗方法。这些发展的最令人兴奋的分支之一是光动力疗法(PDT)。使用特定波长的光和专门设计的光敏物质的组合,PDT为抗击癌症提供了新的视角,细菌感染,和其他对传统治疗方法有抵抗力的疾病。在当今世界,那里的抗药性问题日益严重,寻找替代疗法变得越来越紧迫。想象一下,我们可以用光摧毁癌细胞或细菌,无需使用强化学物质或抗生素。这就是PDT的承诺。通过使用适当调节的光激活光敏剂,这种疗法可以诱导癌症或细菌细胞死亡,同时尽量减少对周围健康组织的损害。在这项工作中,我们将探索这个迷人的方法,发现其作用机制,临床应用,和发展前景。我们还将分析最新的研究和患者的证词,以了解PDT对未来医学的潜力。
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