PDF(Pubmed)
Abstract：
Leishmaniasis is an infectious disease caused by protozoa of the genus Leishmania, which is endemic in certain areas of Europe, such as southern Spain. The disease manifests in various clinical phenotypes, including visceral, cutaneous, mucosal, or asymptomatic leishmaniasis. This diversity in clinical outcomes may be influenced by the host immune response, with human leukocyte antigen (HLA) molecules playing a crucial role in determining susceptibility and progression of the infection. This study explores the association between specific HLA variants and Leishmania infantum infection. We recruited four cohorts: a control group, asymptomatic individuals, patients with symptomatic disease, and cohabitants of infected individuals. HLA typing was performed for all participants, followed by an association analysis with infection status and disease progression. Our findings indicate that the HLA-B*38 and HLA-C*03 alleles are associated with protection against L. infantum infection. These results contribute to a better understanding of the disease\'s progression, offer potential for new therapeutic approaches such as vaccines, and expand the existing knowledge in the literature.
摘要：
利什曼病是由利什曼原虫属原虫引起的传染病,这在欧洲某些地区很流行，比如西班牙南部。这种疾病表现为各种临床表型，包括内脏，皮肤,粘膜，或无症状的利什曼病。这种临床结果的多样性可能受到宿主免疫反应的影响。人类白细胞抗原（HLA）分子在确定感染的易感性和进展中起着至关重要的作用。这项研究探讨了特定的HLA变异与婴儿利什曼原虫感染之间的关联。我们招募了四个队列：一个对照组，无症状个体，有症状的患者，和感染者的同居者。对所有参与者进行HLA分型,然后进行与感染状态和疾病进展的关联分析.我们的发现表明HLA-B*38和HLA-C*03等位基因与针对婴儿乳杆菌感染的保护相关。这些结果有助于更好地了解疾病的进展，为疫苗等新的治疗方法提供了潜力，扩大文献中的现有知识。
