PDF(Pubmed)
Abstract：
BACKGROUND: Telomeres are nucleoprotein complexes at the ends of chromosomes that are under the control of genetic and environmental triggers. Accelerated telomere shortening is causally implicated in the increasing incidence of diseases. The Mediterranean diet has recently been identified as one that confers protection against diseases. This review aimed to identify the effect of each component of the Mediterranean diet on telomere length dynamics, highlighting the underlying molecular mechanisms.
METHODS: PubMed was searched to identify relevant studies to extract data for conducting a narrative review.
RESULTS: The Mediterranean diet alleviates clinical manifestations in many diseases. Focusing on autoimmune diseases, the Mediterranean diet can be protective by preventing inflammation, mitochondrial malfunction, and abnormal telomerase activity. Also, each Mediterranean diet constituent seems to attenuate aging through the sustenance or elongation of telomere length, providing insights into the underlying molecular mechanisms. Polyphenols, vitamins, minerals, and fatty acids seem to be essential in telomere homeostasis, since they inhibit inflammatory responses, DNA damage, oxidative stress, mitochondrial malfunction, and cell death and induce telomerase activation.
CONCLUSIONS: The Mediterranean diet is beneficial for maintaining telomere dynamics and alleviating age-related illnesses. This review provides a comprehensive overview of cross-sectional, observational, and randomized controlled trials regarding the beneficial impact of every constituent in the Mediterranean diet on telomere length and chronic disease management.
METHODS: PubMed was searched to identify relevant studies to extract data for conducting a narrative review.
RESULTS: The Mediterranean diet alleviates clinical manifestations in many diseases. Focusing on autoimmune diseases, the Mediterranean diet can be protective by preventing inflammation, mitochondrial malfunction, and abnormal telomerase activity. Also, each Mediterranean diet constituent seems to attenuate aging through the sustenance or elongation of telomere length, providing insights into the underlying molecular mechanisms. Polyphenols, vitamins, minerals, and fatty acids seem to be essential in telomere homeostasis, since they inhibit inflammatory responses, DNA damage, oxidative stress, mitochondrial malfunction, and cell death and induce telomerase activation.
CONCLUSIONS: The Mediterranean diet is beneficial for maintaining telomere dynamics and alleviating age-related illnesses. This review provides a comprehensive overview of cross-sectional, observational, and randomized controlled trials regarding the beneficial impact of every constituent in the Mediterranean diet on telomere length and chronic disease management.
摘要：
背景：端粒是染色体末端的核蛋白复合物，受遗传和环境触发因素的控制。加速的端粒缩短与疾病发病率的增加有因果关系。地中海饮食最近被认为是一种可以预防疾病的饮食。这篇综述旨在确定地中海饮食的每个组成部分对端粒长度动力学的影响。突出了潜在的分子机制。
方法：搜索PubMed以确定相关研究，以提取数据进行叙述性综述。
结果：地中海饮食可减轻许多疾病的临床表现。专注于自身免疫性疾病，地中海饮食可以预防炎症，线粒体功能障碍,端粒酶活性异常。此外，每个地中海饮食成分似乎通过端粒长度的维持或延长来减轻衰老，提供对潜在分子机制的见解。多酚,维生素,矿物,脂肪酸似乎在端粒体内平衡中是必不可少的，因为它们抑制炎症反应，DNA损伤,氧化应激，线粒体功能障碍,和细胞死亡并诱导端粒酶活化。
结论：地中海饮食有利于维持端粒动力学和减轻与年龄有关的疾病。这篇综述全面概述了横截面，观察,以及关于地中海饮食中每种成分对端粒长度和慢性疾病管理的有益影响的随机对照试验。
方法：搜索PubMed以确定相关研究，以提取数据进行叙述性综述。
结果：地中海饮食可减轻许多疾病的临床表现。专注于自身免疫性疾病，地中海饮食可以预防炎症，线粒体功能障碍,端粒酶活性异常。此外，每个地中海饮食成分似乎通过端粒长度的维持或延长来减轻衰老，提供对潜在分子机制的见解。多酚,维生素,矿物,脂肪酸似乎在端粒体内平衡中是必不可少的，因为它们抑制炎症反应，DNA损伤,氧化应激，线粒体功能障碍,和细胞死亡并诱导端粒酶活化。
结论：地中海饮食有利于维持端粒动力学和减轻与年龄有关的疾病。这篇综述全面概述了横截面，观察,以及关于地中海饮食中每种成分对端粒长度和慢性疾病管理的有益影响的随机对照试验。
