METHODS: Data were derived from an Italian case-control study including 258 pancreatic cancer patients and 551 controls. The cholesterol-lowering diet score was based on seven components: high intakes of (i) non-cellulosic polysaccharides (a proxy of viscous fibers), (ii) monounsaturated fatty acids, (iii) legumes, and (iv) seeds/corn oils (a proxy of phytosterols); and low intakes of (v) saturated fatty acids, (vi) dietary cholesterol, and (vii) food with a high glycemic index. The score was calculated adding one point for each fulfilled component, thus ranging from zero (no adherence) to seven (complete adherence). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated through the logistic regression model.
RESULTS: Scores 5-7 were associated with reduced cancer risk (OR = 0.30; 95% CI: 0.18-0.52) compared to scores 0-2.
CONCLUSIONS: Adherence to a plant-based cholesterol-lowering diet was associated with a reduced risk of pancreatic cancer.
方法:数据来自一项意大利病例对照研究,包括258例胰腺癌患者和551例对照。降低胆固醇的饮食评分基于七个组成部分:(i)非纤维素多糖(粘性纤维的代表)的高摄入量,(ii)单不饱和脂肪酸,(iii)豆类,和(iv)种子/玉米油(植物甾醇的代表);和低摄入量的(v)饱和脂肪酸,(vi)膳食胆固醇,和(vii)血糖指数高的食物。计算分数时,每个完成的组件加一分,因此从零(不坚持)到七(完全坚持)。通过逻辑回归模型估计比值比(OR)和95%置信区间(CI)。
结果:与0-2分相比,5-7分与癌症风险降低相关(OR=0.30;95%CI:0.18-0.52)。
结论:坚持以植物为基础的降胆固醇饮食与胰腺癌风险降低相关。