PDF(Pubmed)
Abstract：
BACKGROUND: Pancreatic cancer risk has been associated with increased serum cholesterol level, which is in turn partially influenced by diet. This study aimed at evaluating the association between pancreatic cancer risk and the adherence to a plant-based cholesterol-lowering diet.
METHODS: Data were derived from an Italian case-control study including 258 pancreatic cancer patients and 551 controls. The cholesterol-lowering diet score was based on seven components: high intakes of (i) non-cellulosic polysaccharides (a proxy of viscous fibers), (ii) monounsaturated fatty acids, (iii) legumes, and (iv) seeds/corn oils (a proxy of phytosterols); and low intakes of (v) saturated fatty acids, (vi) dietary cholesterol, and (vii) food with a high glycemic index. The score was calculated adding one point for each fulfilled component, thus ranging from zero (no adherence) to seven (complete adherence). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated through the logistic regression model.
RESULTS: Scores 5-7 were associated with reduced cancer risk (OR = 0.30; 95% CI: 0.18-0.52) compared to scores 0-2.
CONCLUSIONS: Adherence to a plant-based cholesterol-lowering diet was associated with a reduced risk of pancreatic cancer.
METHODS: Data were derived from an Italian case-control study including 258 pancreatic cancer patients and 551 controls. The cholesterol-lowering diet score was based on seven components: high intakes of (i) non-cellulosic polysaccharides (a proxy of viscous fibers), (ii) monounsaturated fatty acids, (iii) legumes, and (iv) seeds/corn oils (a proxy of phytosterols); and low intakes of (v) saturated fatty acids, (vi) dietary cholesterol, and (vii) food with a high glycemic index. The score was calculated adding one point for each fulfilled component, thus ranging from zero (no adherence) to seven (complete adherence). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated through the logistic regression model.
RESULTS: Scores 5-7 were associated with reduced cancer risk (OR = 0.30; 95% CI: 0.18-0.52) compared to scores 0-2.
CONCLUSIONS: Adherence to a plant-based cholesterol-lowering diet was associated with a reduced risk of pancreatic cancer.
摘要：
背景：胰腺癌风险与血清胆固醇水平升高有关，这反过来又部分受到饮食的影响。这项研究旨在评估胰腺癌风险与坚持植物性降胆固醇饮食之间的关系。
方法：数据来自一项意大利病例对照研究，包括258例胰腺癌患者和551例对照。降低胆固醇的饮食评分基于七个组成部分：（i）非纤维素多糖（粘性纤维的代表）的高摄入量，(ii)单不饱和脂肪酸，(iii)豆类，和（iv）种子/玉米油（植物甾醇的代表）；和低摄入量的（v）饱和脂肪酸，(vi)膳食胆固醇，和(vii)血糖指数高的食物。计算分数时，每个完成的组件加一分，因此从零（不坚持）到七（完全坚持）。通过逻辑回归模型估计比值比（OR）和95％置信区间（CI）。
结果：与0-2分相比，5-7分与癌症风险降低相关（OR=0.30；95％CI：0.18-0.52）。
结论：坚持以植物为基础的降胆固醇饮食与胰腺癌风险降低相关。
方法：数据来自一项意大利病例对照研究，包括258例胰腺癌患者和551例对照。降低胆固醇的饮食评分基于七个组成部分：（i）非纤维素多糖（粘性纤维的代表）的高摄入量，(ii)单不饱和脂肪酸，(iii)豆类，和（iv）种子/玉米油（植物甾醇的代表）；和低摄入量的（v）饱和脂肪酸，(vi)膳食胆固醇，和(vii)血糖指数高的食物。计算分数时，每个完成的组件加一分，因此从零（不坚持）到七（完全坚持）。通过逻辑回归模型估计比值比（OR）和95％置信区间（CI）。
结果：与0-2分相比，5-7分与癌症风险降低相关（OR=0.30；95％CI：0.18-0.52）。
结论：坚持以植物为基础的降胆固醇饮食与胰腺癌风险降低相关。
