PDF(Pubmed)
Abstract：
Glioblastoma (GBM) is a severe form of brain tumor that has a high fatality rate. It grows aggressively and most of the time results in resistance to traditional treatments like chemo- and radiotherapy and surgery. Biodiversity, beyond representing a big resource for human well-being, provides several natural compounds that have shown great potential as anticancer drugs. Many of them are being extensively researched and significantly slow GBM progression by reducing the proliferation rate, migration, and inflammation and also by modulating oxidative stress. Here, the use of some natural compounds, such as Allium lusitanicum, Succisa pratensis, and Dianthus superbus, was explored to tackle GBM; they showed their impact on cell number reduction, which was partially given by cell cycle quiescence. Furthermore, a reduced cell migration ability was reported, accomplished by morphological cytoskeleton changes, which even highlighted a mesenchymal-epithelial transition. Furthermore, metabolic studies showed an induced cell oxidative stress modulation and a massive metabolic rearrangement. Therefore, a new therapeutic option was suggested to overcome the limitations of conventional treatments and thereby improve patient outcomes.
摘要：
胶质母细胞瘤（GBM）是一种严重的脑肿瘤，致死率高。它生长迅速，大多数时候导致对传统治疗如化疗和放疗和手术的抵抗。生物多样性,除了代表人类福祉的重要资源之外，提供了几种天然化合物，显示出作为抗癌药物的巨大潜力。其中许多正在被广泛研究，并通过降低增殖率显着减慢GBM的进展，迁移,和炎症，也通过调节氧化应激。这里,一些天然化合物的使用，比如葱葱,succisapratensis,还有Dianthus超级巴士,被探索以解决GBM；他们展示了他们对细胞数量减少的影响，部分由细胞周期静止给出。此外，据报道，细胞迁移能力降低，通过形态细胞骨架的变化来完成，这甚至突出了间质-上皮转化。此外，代谢研究显示诱导的细胞氧化应激调节和大量的代谢重排。因此,研究人员提出了一种新的治疗选择,以克服常规治疗的局限性,从而改善患者的预后.
