Abstract：
We aimed to determine the risk factors for non-responsiveness to intravenous immunoglobulin (IVIG) and coronary ectasia in Korean children with Kawasaki disease (KD) and compare the efficacy of previously published Japanese and Chinese risk scoring systems in the same cohort. We retrospectively reviewed 459 KD cases diagnosed from January 1, 2013, to December 31, 2022. Age (odds ratio [OR]: 0.983; 95% confidence interval [CI]: 0.968-0.999), change in extremities (OR: 3.308; 95% CI: 1.530-7.151), neutrophils (OR: 1.078; 95% CI: 1.049-1.108), and alanine aminotransferase (OR: 1.002; 95% CI: 1.000-1.004) were identified as independent risk factors for IVIG non-responsiveness, and age (OR: 0.945; 95% CI: 0.902-0.989), C-reactive protein (OR: 1.092; 95% CI: 1.004-1.188), and creatinine kinase (OR: 1.004; 95% CI: 1.001-1.006) were identified as independent risk factors for coronary ectasia. Among previously published risk scoring systems, the Egami (area under the receiver operating characteristics curve [AUC]: 0.695; 95% CI: 0.651-0.737) for IVIG non-responsiveness and the Tang score (AUC: 0.726; 95% CI: 0.578-0.874) for coronary ectasia showed the highest predictive value for our study cohort.
摘要：
我们旨在确定韩国川崎病（KD）儿童对静脉免疫球蛋白（IVIG）无反应和冠状动脉扩张的危险因素，并比较同一队列中先前发表的日本和中国风险评分系统的疗效。我们回顾性分析了从2013年1月1日至2022年12月31日诊断的459例KD病例。年龄（优势比[OR]：0.983；95%置信区间[CI]：0.968-0.999），四肢变化（OR：3.308；95%CI：1.530-7.151），中性粒细胞（OR：1.078；95%CI：1.049-1.108），和丙氨酸氨基转移酶（OR：1.002;95％CI：1.000-1.004）被确定为IVIG无应答的独立危险因素，和年龄（OR：0.945；95%CI：0.902-0.989），C反应蛋白（OR：1.092;95％CI：1.004-1.188），和肌酐激酶（OR：1.004;95％CI：1.001-1.006）被确定为冠状动脉扩张的独立危险因素。在以前公布的风险评分系统中，IVIG无应答性的Egami(受试者工作特征曲线下面积[AUC]:0.695;95%CI:0.651~0.737)和冠状动脉扩张的Tang评分(AUC:0.726;95%CI:0.578~0.874)对我们的研究队列的预测价值最高.
