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Abstract：
BACKGROUND: In China, both percutaneous microwave/radiofrequency ablation liver partition plus portal vein embolization (PALPP) and transarterial chemoembolization (TACE) plus portal vein embolization (PVE) have been utilized in planned hepatectomy. However, there is a lack of comparative studies on the effectiveness of these two techniques for cases with insufficient future liver remnant (FLR).
METHODS: Patients were categorized into either the PALPP group or the TACE + PVE group. Clinical data, including FLR growth rate, complications, secondary resection rate, and overall survival rate, were compared and analyzed for both groups retrospectively.
RESULTS: Between December 2014 and October 2021, a total of 29 patients underwent TACE + PVE (n = 12) and PALPP (n = 17). In the TACE + PVE group, 7 patients successfully underwent two-stage hepatectomy, while in the PALPP group, 13 patients underwent the procedure (two-stage resection rate: 58.3% vs. 76.5%, P = 0.42). There were no significant differences in postoperative complications of one-stage procedures (11.8% vs. 8.3%, P > 0.05) and second-stage resection complication (0% vs. 46.2%, P = 0.05) between the TACE + PVE and PALPP groups. However, the PALPP group demonstrated a shorter time to FLR volume growth for second-stage resection (18.5 days vs. 66 days, P = 0.001) and KGR (58.5 ml/week vs. 7.7 ml/week, P = 0.001).
CONCLUSIONS: Compared with TACE + PVE, PALPP results in a more significant increase in FLR volume and a higher rate of two-stage resection without increasing postoperative complications.
METHODS: Patients were categorized into either the PALPP group or the TACE + PVE group. Clinical data, including FLR growth rate, complications, secondary resection rate, and overall survival rate, were compared and analyzed for both groups retrospectively.
RESULTS: Between December 2014 and October 2021, a total of 29 patients underwent TACE + PVE (n = 12) and PALPP (n = 17). In the TACE + PVE group, 7 patients successfully underwent two-stage hepatectomy, while in the PALPP group, 13 patients underwent the procedure (two-stage resection rate: 58.3% vs. 76.5%, P = 0.42). There were no significant differences in postoperative complications of one-stage procedures (11.8% vs. 8.3%, P > 0.05) and second-stage resection complication (0% vs. 46.2%, P = 0.05) between the TACE + PVE and PALPP groups. However, the PALPP group demonstrated a shorter time to FLR volume growth for second-stage resection (18.5 days vs. 66 days, P = 0.001) and KGR (58.5 ml/week vs. 7.7 ml/week, P = 0.001).
CONCLUSIONS: Compared with TACE + PVE, PALPP results in a more significant increase in FLR volume and a higher rate of two-stage resection without increasing postoperative complications.
摘要：
背景：在中国，经皮微波/射频消融肝分区加门静脉栓塞术(PALPP)和经动脉化疗栓塞术(TACE)加门静脉栓塞术(PVE)均已用于计划的肝切除术.然而,缺乏关于这两种技术对未来肝脏残留(FLR)不足的病例的有效性的比较研究。
方法：患者分为PALPP组和TACE+PVE组。临床数据,包括FLR增长率，并发症,二次切除率,和总生存率，对两组患者进行回顾性对比分析。
结果：2014年12月至2021年10月，共有29例患者接受了TACE+PVE（n=12）和PALPP（n=17）。在TACE+PVE组中，7例患者成功行两期肝切除术,而在PALPP组中，13例患者接受了该手术（两阶段切除率：58.3％vs.76.5%,P=0.42）。一期手术的术后并发症没有显着差异（11.8％vs.8.3%,P>0.05）和二期切除并发症（0%vs.46.2%,TACE+PVE和PALPP组之间的P=0.05）。然而,PALPP组表现出第二阶段切除术的FLR体积增长时间较短(18.5天vs.66天,P=0.001）和KGR（58.5毫升/周vs.7.7毫升/周，P=0.001)。
结论：与TACE+PVE相比，PALPP导致FLR体积的更显着增加，并且两阶段切除术的发生率更高，而不会增加术后并发症。
方法：患者分为PALPP组和TACE+PVE组。临床数据,包括FLR增长率，并发症,二次切除率,和总生存率，对两组患者进行回顾性对比分析。
结果：2014年12月至2021年10月，共有29例患者接受了TACE+PVE（n=12）和PALPP（n=17）。在TACE+PVE组中，7例患者成功行两期肝切除术,而在PALPP组中，13例患者接受了该手术（两阶段切除率：58.3％vs.76.5%,P=0.42）。一期手术的术后并发症没有显着差异（11.8％vs.8.3%,P>0.05）和二期切除并发症（0%vs.46.2%,TACE+PVE和PALPP组之间的P=0.05）。然而,PALPP组表现出第二阶段切除术的FLR体积增长时间较短(18.5天vs.66天,P=0.001）和KGR（58.5毫升/周vs.7.7毫升/周，P=0.001)。
结论：与TACE+PVE相比，PALPP导致FLR体积的更显着增加，并且两阶段切除术的发生率更高，而不会增加术后并发症。
