METHODS: Patients were categorized into either the PALPP group or the TACE + PVE group. Clinical data, including FLR growth rate, complications, secondary resection rate, and overall survival rate, were compared and analyzed for both groups retrospectively.
RESULTS: Between December 2014 and October 2021, a total of 29 patients underwent TACE + PVE (n = 12) and PALPP (n = 17). In the TACE + PVE group, 7 patients successfully underwent two-stage hepatectomy, while in the PALPP group, 13 patients underwent the procedure (two-stage resection rate: 58.3% vs. 76.5%, P = 0.42). There were no significant differences in postoperative complications of one-stage procedures (11.8% vs. 8.3%, P > 0.05) and second-stage resection complication (0% vs. 46.2%, P = 0.05) between the TACE + PVE and PALPP groups. However, the PALPP group demonstrated a shorter time to FLR volume growth for second-stage resection (18.5 days vs. 66 days, P = 0.001) and KGR (58.5 ml/week vs. 7.7 ml/week, P = 0.001).
CONCLUSIONS: Compared with TACE + PVE, PALPP results in a more significant increase in FLR volume and a higher rate of two-stage resection without increasing postoperative complications.
方法:患者分为PALPP组和TACE+PVE组。临床数据,包括FLR增长率,并发症,二次切除率,和总生存率,对两组患者进行回顾性对比分析。
结果:2014年12月至2021年10月,共有29例患者接受了TACE+PVE(n=12)和PALPP(n=17)。在TACE+PVE组中,7例患者成功行两期肝切除术,而在PALPP组中,13例患者接受了该手术(两阶段切除率:58.3%vs.76.5%,P=0.42)。一期手术的术后并发症没有显着差异(11.8%vs.8.3%,P>0.05)和二期切除并发症(0%vs.46.2%,TACE+PVE和PALPP组之间的P=0.05)。然而,PALPP组表现出第二阶段切除术的FLR体积增长时间较短(18.5天vs.66天,P=0.001)和KGR(58.5毫升/周vs.7.7毫升/周,P=0.001)。
结论:与TACE+PVE相比,PALPP导致FLR体积的更显着增加,并且两阶段切除术的发生率更高,而不会增加术后并发症。