PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the profiles and correlations between local and systemic inflammatory molecules in patients with retinitis pigmentosa (RP).
UNASSIGNED: The paired samples of aqueous humor and serum were collected from 36 eyes of 36 typical patients with RP and 25 eyes of age-matched patients with cataracts. The concentration of cytokines/chemokines was evaluated by a multiplexed immunoarray (Q-Plex). The correlations between ocular and serum inflammatory molecules and their association with visual function were analyzed.
UNASSIGNED: The aqueous levels of IL-6, Eotaxin, GROα, I-309, IL-8, IP-10, MCP-1, MCP-2, RANTES, and TARC were significantly elevated in patients with RP compared to controls (all P < 0.05). The detection rate of aqueous IL-23 was higher in patients with RP (27.8%) compared with controls (0%). In patients with RP, Spearman correlation test demonstrated positive correlations for IL-23, I-309, IL-8, and RANTES between aqueous and serum expression levels (IL-23: ⍴ = 0.8604, P < 0.0001; I-309: ρ = 0.4172, P = 0.0113; IL-8: ρ = 0.3325, P = 0.0476; RANTES: ρ = 0.6685, P < 0.0001). In addition, higher aqueous IL-23 was associated with faster visual acuity loss in 10 patients with RP with detected aqueous IL-23 (ρ = 0.4119 and P = 0.0264). Multiple factor analysis confirmed that aqueous and serum IL-23 were associated with visual acuity loss in patients with RP.
UNASSIGNED: These findings suggest that ocular and systemic inflammatory responses have a close interaction in patients with RP. Further longitudinal studies with larger cohorts are needed to explore the correlation between specific inflammatory pathways and the progression of RP.
UNASSIGNED: This study demonstrates the local-systemic interaction of immune responses in patients with RP.
UNASSIGNED: The paired samples of aqueous humor and serum were collected from 36 eyes of 36 typical patients with RP and 25 eyes of age-matched patients with cataracts. The concentration of cytokines/chemokines was evaluated by a multiplexed immunoarray (Q-Plex). The correlations between ocular and serum inflammatory molecules and their association with visual function were analyzed.
UNASSIGNED: The aqueous levels of IL-6, Eotaxin, GROα, I-309, IL-8, IP-10, MCP-1, MCP-2, RANTES, and TARC were significantly elevated in patients with RP compared to controls (all P < 0.05). The detection rate of aqueous IL-23 was higher in patients with RP (27.8%) compared with controls (0%). In patients with RP, Spearman correlation test demonstrated positive correlations for IL-23, I-309, IL-8, and RANTES between aqueous and serum expression levels (IL-23: ⍴ = 0.8604, P < 0.0001; I-309: ρ = 0.4172, P = 0.0113; IL-8: ρ = 0.3325, P = 0.0476; RANTES: ρ = 0.6685, P < 0.0001). In addition, higher aqueous IL-23 was associated with faster visual acuity loss in 10 patients with RP with detected aqueous IL-23 (ρ = 0.4119 and P = 0.0264). Multiple factor analysis confirmed that aqueous and serum IL-23 were associated with visual acuity loss in patients with RP.
UNASSIGNED: These findings suggest that ocular and systemic inflammatory responses have a close interaction in patients with RP. Further longitudinal studies with larger cohorts are needed to explore the correlation between specific inflammatory pathways and the progression of RP.
UNASSIGNED: This study demonstrates the local-systemic interaction of immune responses in patients with RP.
摘要：
■研究色素性视网膜炎（RP）患者局部和全身炎症分子之间的分布和相关性。
■收集了36例典型RP患者的36只眼和25例年龄匹配的白内障患者的配对房水和血清样本。通过多重免疫阵列(Q-Plex)评估细胞因子/趋化因子的浓度。分析眼部和血清炎症分子之间的相关性及其与视功能的关系。
■IL-6，Eotaxin，Groα,I-309,IL-8,IP-10,MCP-1,MCP-2,RANTES,与对照组相比，RP患者的TARC明显升高（均P<0.05）。RP患者的水性IL-23检出率（27.8％）高于对照组（0％）。在RP患者中，Spearman相关性检验显示，房水和血清表达水平之间IL-23，I-309，IL-8和RANTES呈正相关（IL-23：=0.8604，P<0.0001；I-309：ρ=0.4172，P=0.0113；IL-8：ρ=0.3325，P=0.0476；RANTES：ρ=0.6685，P<0.0001）。此外,在10例检测到水性IL-23的RP患者中，较高的水性IL-23与较快的视力下降相关（ρ=0.4119和P=0.0264）。多因素分析证实，房水和血清IL-23与RP患者的视力下降有关。
■这些研究结果表明，在RP患者中，眼部和全身炎症反应有密切的相互作用。需要更大队列的进一步纵向研究来探索特定炎症途径与RP进展之间的相关性。
■这项研究证明了RP患者免疫反应的局部-全身相互作用。
■收集了36例典型RP患者的36只眼和25例年龄匹配的白内障患者的配对房水和血清样本。通过多重免疫阵列(Q-Plex)评估细胞因子/趋化因子的浓度。分析眼部和血清炎症分子之间的相关性及其与视功能的关系。
■IL-6，Eotaxin，Groα,I-309,IL-8,IP-10,MCP-1,MCP-2,RANTES,与对照组相比，RP患者的TARC明显升高（均P<0.05）。RP患者的水性IL-23检出率（27.8％）高于对照组（0％）。在RP患者中，Spearman相关性检验显示，房水和血清表达水平之间IL-23，I-309，IL-8和RANTES呈正相关（IL-23：
■这些研究结果表明，在RP患者中，眼部和全身炎症反应有密切的相互作用。需要更大队列的进一步纵向研究来探索特定炎症途径与RP进展之间的相关性。
■这项研究证明了RP患者免疫反应的局部-全身相互作用。
