%0 Journal Article
%T Ocular and Serum Profiles of Inflammatory Molecules Associated With Retinitis Pigmentosa.
%A Tao Y
%A Fukushima M
%A Shimokawa S
%A Zhao H
%A Okita A
%A Fujiwara K
%A Takeda A
%A Mukai S
%A Sonoda KH
%A Murakami Y
%J Transl Vis Sci Technol
%V 13
%N 8
%D 2024 Aug 1
%M 39120884
%F 3.048
%R 10.1167/tvst.13.8.18
%X <B>UNASSIGNED: </B>To investigate the profiles and correlations between local and systemic inflammatory molecules in patients with retinitis pigmentosa (RP).<BR><B>UNASSIGNED: </B>The paired samples of aqueous humor and serum were collected from 36 eyes of 36 typical patients with RP and 25 eyes of age-matched patients with cataracts. The concentration of cytokines/chemokines was evaluated by a multiplexed immunoarray (Q-Plex). The correlations between ocular and serum inflammatory molecules and their association with visual function were analyzed.<BR><B>UNASSIGNED: </B>The aqueous levels of IL-6, Eotaxin, GROα, I-309, IL-8, IP-10, MCP-1, MCP-2, RANTES, and TARC were significantly elevated in patients with RP compared to controls (all P < 0.05). The detection rate of aqueous IL-23 was higher in patients with RP (27.8%) compared with controls (0%). In patients with RP, Spearman correlation test demonstrated positive correlations for IL-23, I-309, IL-8, and RANTES between aqueous and serum expression levels (IL-23: ⍴ = 0.8604, P < 0.0001; I-309: ρ = 0.4172, P = 0.0113; IL-8: ρ = 0.3325, P = 0.0476; RANTES: ρ = 0.6685, P < 0.0001). In addition, higher aqueous IL-23 was associated with faster visual acuity loss in 10 patients with RP with detected aqueous IL-23 (ρ = 0.4119 and P = 0.0264). Multiple factor analysis confirmed that aqueous and serum IL-23 were associated with visual acuity loss in patients with RP.<BR><B>UNASSIGNED: </B>These findings suggest that ocular and systemic inflammatory responses have a close interaction in patients with RP. Further longitudinal studies with larger cohorts are needed to explore the correlation between specific inflammatory pathways and the progression of RP.<BR><B>UNASSIGNED: </B>This study demonstrates the local-systemic interaction of immune responses in patients with RP.