Abstract：
A sophisticated electrochemical sensor is presented employing a glassy carbon electrode (GCE) modified with a novel composite of synthesized graphitic carbon nitride (g-C3N4) and CoNiO2 bimetallic oxide nanoparticles (g-C3N4/CoNiO2). The sensor\'s electrocatalytic capabilities for Sunitinib (SUNI) oxidation were demonstrated exceptional performance with a calculated detection limit (LOD) of 52.0 nM. The successful synthesis and integrity of the composite were confirmed through meticulous characterization using various techniques. FT-IR analysis affirmed the successful synthesis of g-C3N4/CoNiO2 by providing insights into its molecular structure. XRD, FE-SEM, SEM-EDX, and BET analyses collectively validated the material\'s structural integrity, surface morphology, and electrocatalytic performance. Optimization of key analytical parameters, such as loading volume, concentration, electrolyte solution type, and pH, enhanced the electrocatalytic sensing capabilities of g-C3N4/CoNiO2. The synergistic interaction between g-C3N4 and CoNiO2 bimetallic oxide nanoparticles executed the sensor highly effective in the electrical oxidation of SUNI. Across a concentration range of 0.1-83.8 µM SUNI, the anodic peak current exhibited a linear increase with good precision. Application of the newly developed g-C3N4/CoNiO2 system to detect SUNI in a variety of samples, including urine, human serum, and capsule dosage forms, obtained satisfactory recoveries ranging from 97.1 to 103.0%. This methodology offers a novel approach to underscore the potential of the developed sensor for applications in biological and pharmaceutical monitoring.
摘要：
提出了一种复杂的电化学传感器，该传感器采用了用合成石墨氮化碳（g-C3N4）和CoNiO2双金属氧化物纳米颗粒（g-C3N4/CoNiO2）的新型复合材料修饰的玻碳电极（GCE）。传感器对舒尼替尼（SUNI）氧化的电催化能力被证明具有出色的性能，计算的检测限（LOD）为52.0nM。通过使用各种技术的细致表征，证实了复合材料的成功合成和完整性。FT-IR分析证实了g-C3N4/CoNiO2的成功合成，并提供了对其分子结构的见解。XRD,FE-SEM，SEM-EDX,和BET分析共同验证了材料的结构完整性，表面形态,和电催化性能。关键分析参数的优化，例如加载量，浓度,电解质溶液类型，pH值,增强了g-C3N4/CoNiO2的电催化传感能力。g-C3N4和CoNiO2双金属氧化物纳米颗粒之间的协同相互作用使传感器在SUNI的电氧化中非常有效。在0.1-83.8µMSUNI的浓度范围内，阳极峰值电流呈线性增加，具有良好的精度。应用新开发的g-C3N4/CoNiO2系统检测多种样品中的SUNI，包括尿液,人血清,和胶囊剂型，获得了令人满意的回收率，范围为97.1至103.0%。这种方法提供了一种新颖的方法来强调所开发的传感器在生物和药物监测中的应用潜力。
