PDF(Pubmed)
Abstract：
Adaptation and tolerance to changes in heat and cold temperature are essential for survival and proliferation in plants and animals. However, there is no clear information regarding the common molecules between animals and plants. In this study, we found that heat, and cold tolerance of the nematode Caenorhabditis elegans is oppositely regulated by the RNA-binding protein EMB-4, whose plant homolog contains polymorphism causing heat tolerance diversity. Caenorhabditis elegans alters its cold and heat tolerance depending on the previous cultivation temperature, wherein EMB-4 respectively acts as a positive and negative controller of heat and cold tolerance by altering gene expression. Among the genes whose expression is regulated by EMB-4, a phospholipid scramblase, and an acid sphingomyelinase, which are involved in membrane lipid metabolism, were found to play essential roles in the negative regulation of heat tolerance.
摘要：
对高温和低温变化的适应和耐受性对于植物和动物的生存和增殖至关重要。然而,关于动物和植物之间的共同分子，没有明确的信息。在这项研究中,我们发现热量，线虫秀丽隐杆线虫的耐寒性受RNA结合蛋白EMB-4的相反调节，其植物同源物包含多态性，导致耐热性多样性。秀丽隐杆线虫会根据以前的培养温度改变其对冷和热的耐受性，其中EMB-4通过改变基因表达分别充当耐热和耐冷性的正和负控制器。在表达受EMB-4（一种磷脂加扰酶）调控的基因中，和一种酸性鞘磷脂酶，它们参与膜脂代谢，被发现在耐热性的负调控中起着至关重要的作用。
