METHODS: After obtaining written informed consent, 70 patients were randomly allocated to undergo right-sided EOIB with 20 ml and left-sided RSB with 10 ml of 0.25% bupivacaine at the end of surgery (group ER, n = 35). Patients in the LIA group (n = 35) underwent local infiltration at the port site using 20 ml of the same solution (group LIA, n=35).
RESULTS: The visual analog scale scores with combined EOI and RSB were significantly lower than those with LIA at 1, 2, 4, 8, and 12 h (P < 0.001). Rescue analgesics were required by 65.7% and 14.3% of the patients in the LIA and block groups, respectively (P < 0.001). The time to first rescue analgesic was significantly greater in the ER group than that in the LIA group (2.8 ± 1.10 vs. 1.6 ± 0.50 h; P = 0.012). The number of times rescue analgesia was required was significantly lower in the ER group than that in the LIA group (1.00 ± 0.00 vs. 1.83 ± 0.72; P = 0.015). Nausea and vomiting scores were higher in the LIA group than those in the ER group (P < 0.001). Patient satisfaction scores were higher in the ER group than those in the LIA group.
CONCLUSIONS: EOIB combined with RSB provides superior analgesia compared with LIA and should be considered for LC.
方法:在获得书面知情同意书后,70例患者随机分配在手术结束时接受20ml的右侧EOIB和10ml的0.25%布比卡因的左侧RSB(ER组,n=35)。LIA组患者(n=35)使用20ml相同的溶液在港口部位进行局部浸润(LIA组,n=35)。
结果:EOI和RSB组合的视觉模拟量表评分在1、2、4、8和12h均显着低于LIA(P<0.001)。LIA和阻滞组中65.7%和14.3%的患者需要抢救镇痛药,分别(P<0.001)。ER组首次抢救镇痛时间明显长于LIA组(2.8±1.10vs.1.6±0.50h;P=0.012)。与LIA组相比,ER组需要进行抢救镇痛的次数明显减少(1.00±0.00vs.1.83±0.72;P=0.015)。LIA组恶心呕吐评分高于ER组(P<0.001)。ER组患者满意度评分高于LIA组。
结论:EOIB联合RSB与LIA相比具有更好的镇痛效果,应考虑用于LC。