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Abstract：
BACKGROUND: This study aimed to explore the potential associations between trans fatty acid (TFA) and α-klotho levels.
METHODS: Datasets from the 2009-2010 National Health and Nutrition Examination Survey (NHANES) were analysed for this study. Multivariable linear regression and restricted cubic spline (RCS) analyses were performed to examine the relationships between plasma TFA and serum α-klotho levels.
RESULTS: A total of 1,205 participants were included, with a geometric mean (GM) of 803.60 (95% CI: 787.45, 820.00) pg/mL for serum α-klotho levels. RCS analysis revealed L-shaped relationships between TFA and α-klotho levels. The inflection points for palmitelaidic acid (PA), vaccinic acid (VA), elaidic acid (EA), and total TFA levels were 4.55, 20.50, 18.70, and 46.40 µmol/L, respectively. Before reaching the inflection point, serum α-klotho levels were negatively correlated with plasma PA, VA, EA and total TFA levels, with β values (95% CI) of -0.15 (-0.24, -0.06), -0.16 (-0.23, -0.09), -0.14 (-0.22, -0.05) and - 0.19 (-0.27, -0.11), respectively. Linolelaidic acid (LA) levels exhibited an inverse and linear association with α-klotho levels ( Pnonlinearity=0.167, Poverall<0.001). L-shaped relationships between TFA and α-klotho levels were also observed in the subgroups of participants who were aged < 65 years, were male, did not exercise, were ex-smokers, and were overweight/obese.
CONCLUSIONS: L-shaped correlations between plasma PA, VA, EA, and total TFA levels and serum α-klotho levels were observed among adults in the United States.
METHODS: Datasets from the 2009-2010 National Health and Nutrition Examination Survey (NHANES) were analysed for this study. Multivariable linear regression and restricted cubic spline (RCS) analyses were performed to examine the relationships between plasma TFA and serum α-klotho levels.
RESULTS: A total of 1,205 participants were included, with a geometric mean (GM) of 803.60 (95% CI: 787.45, 820.00) pg/mL for serum α-klotho levels. RCS analysis revealed L-shaped relationships between TFA and α-klotho levels. The inflection points for palmitelaidic acid (PA), vaccinic acid (VA), elaidic acid (EA), and total TFA levels were 4.55, 20.50, 18.70, and 46.40 µmol/L, respectively. Before reaching the inflection point, serum α-klotho levels were negatively correlated with plasma PA, VA, EA and total TFA levels, with β values (95% CI) of -0.15 (-0.24, -0.06), -0.16 (-0.23, -0.09), -0.14 (-0.22, -0.05) and - 0.19 (-0.27, -0.11), respectively. Linolelaidic acid (LA) levels exhibited an inverse and linear association with α-klotho levels ( Pnonlinearity=0.167, Poverall<0.001). L-shaped relationships between TFA and α-klotho levels were also observed in the subgroups of participants who were aged < 65 years, were male, did not exercise, were ex-smokers, and were overweight/obese.
CONCLUSIONS: L-shaped correlations between plasma PA, VA, EA, and total TFA levels and serum α-klotho levels were observed among adults in the United States.
摘要：
背景：本研究旨在探索反式脂肪酸（TFA）与α-klotho水平之间的潜在关联。
方法：分析了2009-2010年国家健康和营养调查（NHANES）的数据。进行了多变量线性回归和限制性三次样条（RCS）分析，以检查血浆TFA和血清α-klotho水平之间的关系。
结果：共纳入1,205名参与者，血清α-klotho水平的几何平均值(GM)为803.60(95%CI:787.45,820.00)pg/mL。RCS分析显示TFA与α-klotho水平呈L型关系。棕榈酸(PA)的拐点，疫苗酸（VA），反油酸（EA），总TFA水平为4.55、20.50、18.70和46.40µmol/L，分别。在到达拐点之前，血清α-klotho水平与血浆PA呈负相关，VA,EA和总TFA水平，β值（95%CI）为-0.15（-0.24，-0.06），-0.16(-0.23,-0.09),-0.14（-0.22，-0.05）和-0.19（-0.27，-0.11），分别。亚油酸（LA）水平与α-klotho水平呈负相关和线性关系（P非线性=0.167，总体<0.001）。在年龄<65岁的参与者亚组中也观察到TFA和α-klotho水平之间的L形关系。是男性，没有锻炼，都是前吸烟者,超重/肥胖。
结论：血浆PA，VA,EA,在美国成年人中观察到总TFA水平和血清α-klotho水平。
方法：分析了2009-2010年国家健康和营养调查（NHANES）的数据。进行了多变量线性回归和限制性三次样条（RCS）分析，以检查血浆TFA和血清α-klotho水平之间的关系。
结果：共纳入1,205名参与者，血清α-klotho水平的几何平均值(GM)为803.60(95%CI:787.45,820.00)pg/mL。RCS分析显示TFA与α-klotho水平呈L型关系。棕榈酸(PA)的拐点，疫苗酸（VA），反油酸（EA），总TFA水平为4.55、20.50、18.70和46.40µmol/L，分别。在到达拐点之前，血清α-klotho水平与血浆PA呈负相关，VA,EA和总TFA水平，β值（95%CI）为-0.15（-0.24，-0.06），-0.16(-0.23,-0.09),-0.14（-0.22，-0.05）和-0.19（-0.27，-0.11），分别。亚油酸（LA）水平与α-klotho水平呈负相关和线性关系（P非线性=0.167，总体<0.001）。在年龄<65岁的参与者亚组中也观察到TFA和α-klotho水平之间的L形关系。是男性，没有锻炼，都是前吸烟者,超重/肥胖。
结论：血浆PA，VA,EA,在美国成年人中观察到总TFA水平和血清α-klotho水平。
