METHODS:
METHODS: This cross-sectional study analyzed data from the NHANES conducted between 1999 and 2006. Reproductive health was assessed through questionnaires, and the TyG index was derived from fasting triglyceride and glucose measurements. Weighted logistic regression models were used to analyze the relationship between the TyG index and endometriosis. Restricted cubic spline (RCS) curves explored the linear relationship, while stratified and sensitivity analyses assessed potential interactions and the robustness of the findings.
RESULTS: The study included 2,346 women, with 176 diagnosed with endometriosis and 2,170 without. Women with endometriosis exhibited an elevated TyG index compared to those without the condition. The weighted logistic regression analysis revealed that the TyG index is an independent risk factor for endometriosis (OR = 1.58, 95% CI 1.17-2.14, p = 0.004). RCS analysis indicated a significant positive linear association between the TyG index and endometriosis, with a turning point at 8.51. Subgroup analysis indicated a stronger association in certain populations. The post-propensity score matching analysis confirmed the robustness of these findings.
CONCLUSIONS: In the U.S. population, a higher TyG index is positively and linearly associated with endometriosis prevalence. Effective management of blood glucose and lipid levels may reduce the prevalence of endometriosis.
方法:
方法:本横断面研究分析了1999年至2006年NHANES的数据。通过问卷调查评估生殖健康,TyG指数来自空腹甘油三酯和血糖测量。采用加权logistic回归模型分析TyG指数与子宫内膜异位症的关系。受限三次样条(RCS)曲线探索了线性关系,而分层和敏感性分析评估了潜在的相互作用和结果的稳健性.
结果:该研究包括2,346名女性,与176诊断为子宫内膜异位症和2,170没有。与没有子宫内膜异位症的女性相比,患有子宫内膜异位症的女性表现出升高的TyG指数。加权logistic回归分析显示,TyG指数是子宫内膜异位症的独立危险因素(OR=1.58,95%CI1.17~2.14,p=0.004)。RCS分析表明TyG指数与子宫内膜异位症之间存在显著的正线性相关,转折点是8.51。亚组分析表明在某些人群中具有更强的关联。后倾向得分匹配分析证实了这些发现的稳健性。
结论:在美国人口中,较高的TyG指数与子宫内膜异位症患病率呈线性正相关.有效控制血糖和血脂水平可降低子宫内膜异位症的患病率。