Abstract：
The gut-liver axis plays a pivotal role in maintaining body homeostasis. Disruption of the gut-liver axis is linked to a multitude of diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Probiotic strains from the Lactobacillaceae family are commonly used to mitigate experimental MASLD. Over the years, numerous studies have demonstrated the efficacy of these probiotics, often focusing on the outcome of liver disease. This review aims to further understand MASLD as a systemic metabolic dysfunction and to highlight the effects of probiotics on multi-organ axis, including organs such as the gastrointestinal tract, pancreas, muscle, adipose tissue, and the immune system. We specifically discuss evidence on how supplementation with Lactobacillaceae strains may alleviate MASLD by not only restoring liver health but also by modulating the physiology of other organ systems.
摘要：
肠-肝轴在维持身体稳态中起着关键作用。肠-肝轴的破坏与多种疾病有关，包括代谢功能障碍相关的脂肪变性肝病（MASLD）。来自乳杆菌科的益生菌菌株通常用于减轻实验性MASLD。多年来,许多研究已经证明了这些益生菌的功效，经常关注肝病的结果。这篇综述旨在进一步了解MASLD作为一种全身代谢功能障碍，并强调益生菌对多器官轴的影响，包括胃肠道等器官，胰腺,肌肉，脂肪组织,和免疫系统。我们专门讨论了补充乳杆菌科菌株如何通过不仅恢复肝脏健康，而且通过调节其他器官系统的生理学来减轻MASLD的证据。
