Abstract：
BACKGROUND: The optimal modality for renal replacement therapy (RRT) in patients venoarterial extracorporeal membrane oxygenation (VA-ECMO) remains unclear. This study aimed to compare outcomes between continuous renal replacement therapy (CRRT) and peritoneal dialysis (PD) in VA-ECMO patients.
METHODS: This single-center retrospective study included VA-ECMO patients who developed AKI and subsequently required CRRT or PD. Data on patient demographics, comorbidities, clinical characteristics, RRT modality, and outcomes were collected. The primary outcome was in-hospital mortality, with secondary outcomes including length of stays, RRT durations, and complications associated with RRT.
RESULTS: A total of 43 patients were included (72.1% male, mean age 58.2 ± 15.7 years). Of these, 21 received CRRT and 22 received PD during ECMO therapy. In-hospital mortality rates did not significantly differ between CRRT and PD groups (80.9% vs 90.9%, p = 0.35). However, PD was associated with a higher incidence of catheter-related complications, including malposition (31.8% vs 4.7%, p = 0.046), infection (22.7% vs 4.7%, p = 0.19), and bleeding (18.2% vs 9.5%, p = 0.66), respectively.
CONCLUSIONS: Among patients receiving VA-ECMO-supported RRT, our study revealed comparable in-hospital mortality rates between CRRT and PD, although PD was associated with a higher incidence of catheter-related complications.
METHODS: This single-center retrospective study included VA-ECMO patients who developed AKI and subsequently required CRRT or PD. Data on patient demographics, comorbidities, clinical characteristics, RRT modality, and outcomes were collected. The primary outcome was in-hospital mortality, with secondary outcomes including length of stays, RRT durations, and complications associated with RRT.
RESULTS: A total of 43 patients were included (72.1% male, mean age 58.2 ± 15.7 years). Of these, 21 received CRRT and 22 received PD during ECMO therapy. In-hospital mortality rates did not significantly differ between CRRT and PD groups (80.9% vs 90.9%, p = 0.35). However, PD was associated with a higher incidence of catheter-related complications, including malposition (31.8% vs 4.7%, p = 0.046), infection (22.7% vs 4.7%, p = 0.19), and bleeding (18.2% vs 9.5%, p = 0.66), respectively.
CONCLUSIONS: Among patients receiving VA-ECMO-supported RRT, our study revealed comparable in-hospital mortality rates between CRRT and PD, although PD was associated with a higher incidence of catheter-related complications.
摘要：
背景：患者静脉动脉体外膜氧合（VA-ECMO）的肾脏替代疗法（RRT）的最佳方式仍不清楚。这项研究旨在比较VA-ECMO患者的连续性肾脏替代治疗（CRRT）和腹膜透析（PD）的结果。
方法：此单中心回顾性研究包括发生AKI并随后需要CRRT或PD的VA-ECMO患者。患者人口统计数据，合并症,临床特征,RRT模态,并收集结果。主要结果是住院死亡率，次要结果包括住院时间，RRT持续时间,以及与RRT相关的并发症。
结果：共纳入43例患者（72.1%为男性，平均年龄58.2±15.7岁)。其中,在ECMO治疗期间，21人接受CRRT，22人接受PD。CRRT组和PD组之间的住院死亡率没有显着差异（80.9％vs90.9％，p=0.35)。然而,PD与导管相关并发症发生率较高相关,包括错位(31.8%对4.7%，p=0.046),感染（22.7%vs4.7%，p=0.19),和出血（18.2%vs9.5%，p=0.66),分别。
结论：在接受VA-ECMO支持的RRT的患者中，我们的研究显示，CRRT和PD的住院死亡率相当，尽管PD与导管相关并发症的发生率较高相关。
方法：此单中心回顾性研究包括发生AKI并随后需要CRRT或PD的VA-ECMO患者。患者人口统计数据，合并症,临床特征,RRT模态,并收集结果。主要结果是住院死亡率，次要结果包括住院时间，RRT持续时间,以及与RRT相关的并发症。
结果：共纳入43例患者（72.1%为男性，平均年龄58.2±15.7岁)。其中,在ECMO治疗期间，21人接受CRRT，22人接受PD。CRRT组和PD组之间的住院死亡率没有显着差异（80.9％vs90.9％，p=0.35)。然而,PD与导管相关并发症发生率较高相关,包括错位(31.8%对4.7%，p=0.046),感染（22.7%vs4.7%，p=0.19),和出血（18.2%vs9.5%，p=0.66),分别。
结论：在接受VA-ECMO支持的RRT的患者中，我们的研究显示，CRRT和PD的住院死亡率相当，尽管PD与导管相关并发症的发生率较高相关。
