PDF(Pubmed)
Abstract：
UNASSIGNED: The purpose of this study was to determine the effects of ambient lighting on intraocular pressure (IOP) rhythmicity and variability.
UNASSIGNED: IOP was continuously recorded by wireless telemetry from rats under light/dark (LD), dark/light (DL), asymmetric (6L18D and 18D6L), constant dark (DD), and constant light (LL) cycles. In some DD experiments, 1-hour light pulses were presented at varying times. IOP rhythmicity and variability were respectively quantified via cosinor analysis and peak detection algorithms that identified transient and sustained fluctuations.
UNASSIGNED: Rat IOP peaked at night and troughed during the day with LD amplitude of 8.7 ± 3.4 mm Hg. Rhythmicity persisted in DD and LL with a free-running period of 24.1 ± 0.3 and 25.2 ± 0.4 hours, respectively. Peak-to-trough amplitude was approximately 60% smaller in LL, often disappeared after 1 to 2 weeks as daytime IOP drifted 2.6 ± 1.5 mm Hg higher, and returned to approximately 60% larger in LD. Rhythmicity was similarly impacted but resynchronized to DL over 4 to 6 days. Rhythmicity was unaltered by short photoperiods (6L18D), but the nocturnal IOP elevation was markedly shortened by long photoperiods (18L6D) and temporarily lowered to daytime levels by light pulses during the subjective night. Transient and sustained event rate, amplitude, interval, and energy content were nearly identical in LD, DD, and LL.
UNASSIGNED: Aqueous humor dynamics of rat eyes are intrinsically configured to set IOP at daytime levels. Circadian clock input modulates these dynamics to elevate IOP at night. Light at night blocks this input, sending IOP back to daytime levels. Effects of abnormal lighting on IOP rhythmicity may contribute to pressure-related ocular neuropathies.
UNASSIGNED: IOP was continuously recorded by wireless telemetry from rats under light/dark (LD), dark/light (DL), asymmetric (6L18D and 18D6L), constant dark (DD), and constant light (LL) cycles. In some DD experiments, 1-hour light pulses were presented at varying times. IOP rhythmicity and variability were respectively quantified via cosinor analysis and peak detection algorithms that identified transient and sustained fluctuations.
UNASSIGNED: Rat IOP peaked at night and troughed during the day with LD amplitude of 8.7 ± 3.4 mm Hg. Rhythmicity persisted in DD and LL with a free-running period of 24.1 ± 0.3 and 25.2 ± 0.4 hours, respectively. Peak-to-trough amplitude was approximately 60% smaller in LL, often disappeared after 1 to 2 weeks as daytime IOP drifted 2.6 ± 1.5 mm Hg higher, and returned to approximately 60% larger in LD. Rhythmicity was similarly impacted but resynchronized to DL over 4 to 6 days. Rhythmicity was unaltered by short photoperiods (6L18D), but the nocturnal IOP elevation was markedly shortened by long photoperiods (18L6D) and temporarily lowered to daytime levels by light pulses during the subjective night. Transient and sustained event rate, amplitude, interval, and energy content were nearly identical in LD, DD, and LL.
UNASSIGNED: Aqueous humor dynamics of rat eyes are intrinsically configured to set IOP at daytime levels. Circadian clock input modulates these dynamics to elevate IOP at night. Light at night blocks this input, sending IOP back to daytime levels. Effects of abnormal lighting on IOP rhythmicity may contribute to pressure-related ocular neuropathies.
摘要：
■这项研究的目的是确定环境照明对眼内压（IOP）节律性和变异性的影响。
■在明/暗（LD）下通过无线遥测连续记录大鼠的IOP，暗/光(DL),不对称（6L18D和18D6L），恒定暗(DD)，和恒定光(LL)周期。在某些DD实验中，在不同的时间出现1小时的光脉冲。通过识别瞬时和持续波动的余弦分析和峰值检测算法分别量化IOP节律性和变异性。
■大鼠眼压在夜间达到峰值，白天下降，LD振幅为8.7±3.4mmHg。DD和LL的节律性持续，自由运行时间为24.1±0.3和25.2±0.4小时，分别。LL的峰谷幅度大约小60%，通常在1到2周后消失，因为白天IOP漂移了2.6±1.5mmHg，并恢复到LD大约60%。节律性受到类似影响，但在4至6天内与DL重新同步。短光周期(6L18D)不会改变节律性，但是夜间IOP升高因长光周期（18L6D）而明显缩短，并在主观夜晚因光脉冲而暂时降低至白天水平。短暂性和持续性事件发生率,振幅,间隔,和能量含量在LD中几乎相同，DD,和LL。
■大鼠眼睛的房水动力学本质上被配置为将IOP设置在白天水平。昼夜节律时钟输入调制这些动态以在夜间提高IOP。夜晚的灯光阻挡了这种输入，将IOP恢复到白天水平。异常光照对IOP节律性的影响可能导致与压力相关的眼部神经病变。
■在明/暗（LD）下通过无线遥测连续记录大鼠的IOP，暗/光(DL),不对称（6L18D和18D6L），恒定暗(DD)，和恒定光(LL)周期。在某些DD实验中，在不同的时间出现1小时的光脉冲。通过识别瞬时和持续波动的余弦分析和峰值检测算法分别量化IOP节律性和变异性。
■大鼠眼压在夜间达到峰值，白天下降，LD振幅为8.7±3.4mmHg。DD和LL的节律性持续，自由运行时间为24.1±0.3和25.2±0.4小时，分别。LL的峰谷幅度大约小60%，通常在1到2周后消失，因为白天IOP漂移了2.6±1.5mmHg，并恢复到LD大约60%。节律性受到类似影响，但在4至6天内与DL重新同步。短光周期(6L18D)不会改变节律性，但是夜间IOP升高因长光周期（18L6D）而明显缩短，并在主观夜晚因光脉冲而暂时降低至白天水平。短暂性和持续性事件发生率,振幅,间隔,和能量含量在LD中几乎相同，DD,和LL。
■大鼠眼睛的房水动力学本质上被配置为将IOP设置在白天水平。昼夜节律时钟输入调制这些动态以在夜间提高IOP。夜晚的灯光阻挡了这种输入，将IOP恢复到白天水平。异常光照对IOP节律性的影响可能导致与压力相关的眼部神经病变。
