Abstract：
OBJECTIVE: We aimed to investigate whether prediction of liver fibrosis using two-dimensional shear wave elastography (2D-SWE) and vascular tree grading using superb microvascular imaging (SMI) are useful for postoperative follow-up in patients with biliary atresia (BA).
METHODS: We retrospectively collected data from medical records of 134 patients who underwent ultrasound examination with 2D-SWE or SMI, including 13 postoperative patients with BA and 121 non-BA patients. We investigated the distribution of liver stiffness values with SWE and vascular tree grading with SMI and evaluated correlations between these findings and biochemical indices of liver fibrosis in postoperative BA patients.
RESULTS: The SWE values of the BA group were not significantly different from that of any other disease groups in non-BA patients. In postoperative BA patients, SWE values correlated significantly with aspartate aminotransferase to platelet ratio index (Spearman rank correlation coefficient [rs] = 0.6380, p = 0.0256) and with the Fib-4 index (rs = 0.6526, p = 0.0214). SMI vascular tree grading of the BA group was significantly higher than that of the choledochal cyst group (p = 0.0008) and other hepatobiliary disorder group (p = 0.0030). In postoperative BA patients, SMI vascular tree grading was not positively correlated with any biochemical marker of fibrosis.
CONCLUSIONS: 2D-SWE appears to be useful for follow-up in postoperative BA patients.
METHODS: We retrospectively collected data from medical records of 134 patients who underwent ultrasound examination with 2D-SWE or SMI, including 13 postoperative patients with BA and 121 non-BA patients. We investigated the distribution of liver stiffness values with SWE and vascular tree grading with SMI and evaluated correlations between these findings and biochemical indices of liver fibrosis in postoperative BA patients.
RESULTS: The SWE values of the BA group were not significantly different from that of any other disease groups in non-BA patients. In postoperative BA patients, SWE values correlated significantly with aspartate aminotransferase to platelet ratio index (Spearman rank correlation coefficient [rs] = 0.6380, p = 0.0256) and with the Fib-4 index (rs = 0.6526, p = 0.0214). SMI vascular tree grading of the BA group was significantly higher than that of the choledochal cyst group (p = 0.0008) and other hepatobiliary disorder group (p = 0.0030). In postoperative BA patients, SMI vascular tree grading was not positively correlated with any biochemical marker of fibrosis.
CONCLUSIONS: 2D-SWE appears to be useful for follow-up in postoperative BA patients.
摘要：
目的：我们旨在研究使用二维剪切波弹性成像（2D-SWE）和使用超微血管成像（SMI）的血管树分级预测肝纤维化是否有助于胆道闭锁（BA）患者的术后随访。
方法：我们从134例接受2D-SWE或SMI超声检查的患者的病历中收集数据，包括13例BA和121例非BA患者。我们调查了SWE和SMI的血管树分级的肝脏硬度值的分布，并评估了这些发现与术后BA患者肝纤维化的生化指标之间的相关性。
结果：在非BA患者中，BA组的SWE值与任何其他疾病组的SWE值没有显著差异。在术后BA患者中，SWE值与天冬氨酸氨基转移酶与血小板比率指数（Spearman等级相关系数[rs]=0.6380，p=0.0256）和Fib-4指数（rs=0.6526，p=0.0214）显着相关。BA组SMI血管树分级明显高于胆总管囊肿组(p=0.0008)和其他肝胆疾病组(p=0.0030)。在术后BA患者中，SMI血管树分级与纤维化的任何生化指标均不呈正相关。
结论：2D-SWE似乎可用于BA患者术后随访。
方法：我们从134例接受2D-SWE或SMI超声检查的患者的病历中收集数据，包括13例BA和121例非BA患者。我们调查了SWE和SMI的血管树分级的肝脏硬度值的分布，并评估了这些发现与术后BA患者肝纤维化的生化指标之间的相关性。
结果：在非BA患者中，BA组的SWE值与任何其他疾病组的SWE值没有显著差异。在术后BA患者中，SWE值与天冬氨酸氨基转移酶与血小板比率指数（Spearman等级相关系数[rs]=0.6380，p=0.0256）和Fib-4指数（rs=0.6526，p=0.0214）显着相关。BA组SMI血管树分级明显高于胆总管囊肿组(p=0.0008)和其他肝胆疾病组(p=0.0030)。在术后BA患者中，SMI血管树分级与纤维化的任何生化指标均不呈正相关。
结论：2D-SWE似乎可用于BA患者术后随访。
