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Abstract：
OBJECTIVE: To explore whether previous participation in clinical studies increases adherence to management guidelines in acute uncomplicated diverticulitis (AUD).
METHODS: This retrospective cohort study was designed to give a SNAPSHOT of the management of AUD at six hospitals, three of which had participated in the AVOD trial comparing antibiotic versus non-antibiotic treatment of AUD. Patients with AUD were included from March 2019 through June 2020 and followed for 90 days. The primary outcome was treatment of AUD categorised by antibiotic treatment and inpatient or outpatient management compared between AVOD and non-AVOD hospitals. Descriptive statistics were compiled, and differences between hospitals were assessed with Pearson\'s chi-squared test.
RESULTS: The cohort included 449 patients with AUD of which 63% were women and the median age was 63 (IQR: 52-73) years. Patient characteristics were comparable across the hospitals. Antibiotics were administered to 84 (19%) patients and 113 (25%) patients were managed as inpatients. Management varied significantly between AVOD and non-AVOD hospitals. The mean proportion of patients treated with antibiotics was 7% at AVOD hospitals compared to 38% at non-AVOD hospitals (p < 0.001). The mean proportion of in-hospital management was 18% at AVOD hospitals versus 38% at non-AVOD hospitals (p < 0.001).
CONCLUSIONS: Most patients with AUD were managed according to current guidelines. However, the management varies between hospitals and previous participation in clinical studies may increase knowledge of and adherence to guidelines.
METHODS: This retrospective cohort study was designed to give a SNAPSHOT of the management of AUD at six hospitals, three of which had participated in the AVOD trial comparing antibiotic versus non-antibiotic treatment of AUD. Patients with AUD were included from March 2019 through June 2020 and followed for 90 days. The primary outcome was treatment of AUD categorised by antibiotic treatment and inpatient or outpatient management compared between AVOD and non-AVOD hospitals. Descriptive statistics were compiled, and differences between hospitals were assessed with Pearson\'s chi-squared test.
RESULTS: The cohort included 449 patients with AUD of which 63% were women and the median age was 63 (IQR: 52-73) years. Patient characteristics were comparable across the hospitals. Antibiotics were administered to 84 (19%) patients and 113 (25%) patients were managed as inpatients. Management varied significantly between AVOD and non-AVOD hospitals. The mean proportion of patients treated with antibiotics was 7% at AVOD hospitals compared to 38% at non-AVOD hospitals (p < 0.001). The mean proportion of in-hospital management was 18% at AVOD hospitals versus 38% at non-AVOD hospitals (p < 0.001).
CONCLUSIONS: Most patients with AUD were managed according to current guidelines. However, the management varies between hospitals and previous participation in clinical studies may increase knowledge of and adherence to guidelines.
摘要：
目的：探讨既往参与临床研究是否能提高急性非复杂性憩室炎（AUD）患者对治疗指南的依从性。
方法：这项回顾性队列研究旨在对六家医院的AUD管理进行快照，其中3例参与了AVOD试验,比较了抗生素和非抗生素对AUD的治疗.从2019年3月至2020年6月纳入AUD患者，随访90天。主要结果是与AVOD和非AVOD医院相比，按抗生素治疗和住院或门诊管理分类的AUD治疗。编制了描述性统计数据，医院之间的差异用皮尔森卡方检验进行评估。
结果：该队列包括449例AUD患者，其中63％为女性，中位年龄为63（IQR：52-73）岁。不同医院的患者特征具有可比性。84例（19%）患者服用抗生素，113例（25%）患者作为住院患者进行管理。AVOD和非AVOD医院之间的管理差异很大。AVOD医院接受抗生素治疗的患者平均比例为7%，而非AVOD医院为38%(p<0.001)。AVOD医院内管理的平均比例为18％，非AVOD医院为38％（p<0.001）。
结论：大多数AUD患者根据当前指南进行治疗。然而,医院之间的管理不同,以前参与临床研究可能会增加对指南的了解和依从性.
方法：这项回顾性队列研究旨在对六家医院的AUD管理进行快照，其中3例参与了AVOD试验,比较了抗生素和非抗生素对AUD的治疗.从2019年3月至2020年6月纳入AUD患者，随访90天。主要结果是与AVOD和非AVOD医院相比，按抗生素治疗和住院或门诊管理分类的AUD治疗。编制了描述性统计数据，医院之间的差异用皮尔森卡方检验进行评估。
结果：该队列包括449例AUD患者，其中63％为女性，中位年龄为63（IQR：52-73）岁。不同医院的患者特征具有可比性。84例（19%）患者服用抗生素，113例（25%）患者作为住院患者进行管理。AVOD和非AVOD医院之间的管理差异很大。AVOD医院接受抗生素治疗的患者平均比例为7%，而非AVOD医院为38%(p<0.001)。AVOD医院内管理的平均比例为18％，非AVOD医院为38％（p<0.001）。
结论：大多数AUD患者根据当前指南进行治疗。然而,医院之间的管理不同,以前参与临床研究可能会增加对指南的了解和依从性.
